17 Result(s)

Article

The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection

We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-inf...

Anne Horn, C. Scheller, S. du Plessis, R. Burger… in Journal of Neural Transmission (2017)

Article

Increased dopaminergic neurotransmission in therapy-naïve asymptomatic HIV patients is not associated with adaptive changes at the dopaminergic synapses

Central dopaminergic (DA) systems are affected during human immunodeficiency virus (HIV) infection. So far, it is believed that they degenerate with progression of HIV disease because deterioration of DA syste...

C. Scheller, G. Arendt, T. Nolting, C. Antke, S. Sopper… in Journal of Neural Transmission (2010)

Article

Substantia nigra hyperechogenicity and CSF dopamine depletion in HIV

Dopaminergic dysfunction is thought to play a pivotal role in human immunodeficiency virus (HIV)-related dementia. Decreased dopamine (DA) levels in the cerebrospinal fluid (CSF) and neuronal loss in the subst...

Mark Obermann, M. Küper, O. Kastrup, O. Yaldizli, S. Esser… in Journal of Neurology (2009)

Article

Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis

Impaired oxidative stress defense has been reported in blood of both drug-naïve and antipsychotic-treated patients suffering from schizophrenic psychosis, indicating the involvement of free radical metabolism ...

T. M. Michel, J. Thome, D. Martin, K. Nara, S. Zwerina… in Journal of Neural Transmission (2004)

Article

Dopamine deficits and regulation of the cAMP second messenger system in brains of simian immunodeficiency virus-infected rhesus monkeys

The basal ganglia, structures rich in the neurotransmitter dopamine, are primarily affected during human immunodeficiency virus (HIV) infection. The authors measured levels of dopamine and its metabolites, hom...

M. Jenuwein, C. Scheller, E. Neuen-Jacob, S. Sopper… in Journal of NeuroVirology (2004)

Article

Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs

Drug abuse and human immunodeficiency virus (HIV) infection seem to cause cumulative damage in the central nervous system (CNS). Elevated extracellular dopamine is thought to be a prime mediator of the reinfor...

S. Czub, M. Czub, E. Koutsilieri, S. Sopper, F. Villinger… in Acta Neuropathologica (2004)

Article

Free radicals in Parkinson's disease

Although there are a number of hypotheses to explain the pathobiochemistry of Parkinson's disease (PD), the one on oxidative stress (OS) has gained major interest. The evidence for OS participation as a cause...

E. Koutsilieri, C. Scheller, E. Grünblatt, K. Nara, J. Li… in Journal of Neurology (2002)

Article

Methylmercury induces neurite degeneration in primary culture of mouse dopaminergic mesencephalic cells

Methylmercury cation (MeHg) is an hazardous environmental pollutant with neurotoxic action. Little is known about the effects of MeHg on catecholaminergic neurons. In the present study we have used epifluores...

M. E. Götz, E. Koutsilieri, P. Riederer, S. Ceccatelli… in Journal of Neural Transmission (2002)

Article

Parkinsonism in HIV dementia

A great number of human immunodeficiency virus (HIV)-infected patients develop a central nervous system disorder, commonly called HIV dementia or AIDS dementia complex (ADC). HIV dementia is independent of op...

E. Koutsilieri, S. Sopper, C. Scheller, V. ter Meulen… in Journal of Neural Transmission (2002)

Article

Macaque animal model for HIV-induced neurological disease

The pathogenesis of HIV-induced neurological disorders is still incompletely understood. Since many aspects of this disease are difficult to explore in humans, animal models are necessary to fill the gaps in ...

S. Sopper, E. Koutsilieri, C. Scheller, S. Czub… in Journal of Neural Transmission (2002)

Article

Involvement of dopamine in the progression of AIDS Dementia Complex

HIV compromises immunological functions. Immune responses are regulated to a great extent by several molecules such as cytokines, neurotransmitters and hormones which interact with different immune effector c...

E. Koutsilieri, S. Sopper, C. Scheller, V. ter Meulen… in Journal of Neural Transmission (2002)

Article

Dopamine activates HIV in chronically infected T lymphoblasts

HIV infection is associated with a marked vulnerability of the dopaminergic system. We found recently that dopaminergic substances increase brain pathology in the simian model of HIV infection. In the current...

C. Scheller, S. Sopper, C. Jassoy, V. ter Meulen… in Journal of Neural Transmission (2000)

Article

Abstracts Second Congress of the European Society for Clinical Neuropharmacology

Y. Agid, T. Arendt, U. Gärtner, M. Holzer… in Journal of Neural Transmission / General S… (1995)

Article

MPP⁺ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/B16 mice

1-Methyl-4-phenylpyridinium (MPP⁺), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) serves as a valuable tool in animal models of Parkinson's disease. Primary cell cultures of mesence...

T. S. Chen, E. Koutsilieri, W. D. Rausch in Journal of Neural Transmission / General S… (1995)

Article

Functional changes in cocultures of mesencephalon and striatal neurons from embryonic C57/BL6 mice due to low concentrations of 1-Methyl-4-Phenylpyridinium (MPP⁺)

1-Methyl-4-phenylpyridinium (MPP⁺), the active metabolite of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is taken up into dopaminergic terminals and selectively destroys dopaminergic neurons, serving a...

E. Koutsilieri, W. W. Chan, D. Reinitzer… in Journal of Neural Transmission / General S… (1993)