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  1. Article

    Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes

    To characterize the molecular mechanisms of nitrofen-induced pulmonary hypoplasia.

    Qiang-song Tong, Li-duan Zheng, Shao-tao Tang, Guo-song Jiang… in Acta Pharmacologica Sinica (2007)

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  2. Article

    Natural jasmonates of different structures suppress the growth of human neuroblastoma cell line SH-SY5Y and its mechanisms

    Recent evidence has indicated that members of natural jasmonates, a family of plant stress hormones, exhibit anticancer activity. The current study was undertaken to investigate the effects of jasmonates on the i...

    Qiang-song Tong, Guo-song Jiang, Li-duan Zheng, Shao-tao Tang… in Acta Pharmacologica Sinica (2008)

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  3. Article

    Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation

    The phosphorylation of histone H2AX, a novel tumor suppressor protein, is involved in regulation of cancer cell apoptosis. The aim of this study was to examine whether H2AX phosphorylation was required for res...

    **n-pin Wu, Min **ong, Cheng-shan Xu, Lian-ning Duan… in Acta Pharmacologica Sinica (2015)

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    Article

    Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model

    Pulmonary fibrosis is a life-threatening disease characterized by progressive dyspnea and worsening of pulmonary function. No effective therapeutic strategy for pulmonary fibrosis has been established. Aucubin...

    Yong Zhou, ** Li, Jia-** Duan, Tian Liu, **n-**n Guan, Wen-**u Mei… in Inflammation (2017)

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    Article

    Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice

    Autotaxin-lysophosphatidic acid (ATX-LPA) axis is closely associated with several inflammation-related diseases. In the colonic mucosa of patients with chronic ulcerative colitis (UC), the expression of ATX an...

    Ya-Lan Dong, Xue-Yun Duan, Yu-** Liu, Heng Fan, Meng Xu, Qian-Yun Chen… in Inflammation (2019)

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    Article

    SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma

    PI3Kδ is expressed predominately in leukocytes and overexpressed in B-cell-related malignances. PI3Kδ has been validated as a promising target for cancer therapy, and specific PI3Kδ inhibitors were approved fo...

    ** Zhang, Yu-ting Duan, Yi Wang, **ng-dong Zhao, Yi-ming Sun… in Acta Pharmacologica Sinica (2022)

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    Article

    Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome

    Ischemic stroke is a major cause of disability and death worldwide, and its management requires urgent attention. Previous studies have shown that vagus nerve stimulation (VNS) exerts neuroprotection in ischem...

    **ao-mei **a, Yu Duan, Yue-** Wang, Rui-xue Han… in Acta Pharmacologica Sinica (2024)

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    Article

    FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis

    The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of public health concerns. The activation of FXR shows promise to co...

    Ying-quan Wen, Zi-yuan Zou, Guan-guan Zhao, Meng-jiao Zhang… in Acta Pharmacologica Sinica (2024)