Skip to main content

11 Result(s)

within Agriculture Remove this filter Cancer Research Remove this filter Gene Function Remove this filter Dieter Flesch-Janys Remove this filter Article Remove this filter

and

  1. No Access

    Article

    A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

    The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknow...

    Lang Wu, Wei Shi, Jirong Long, **ngyi Guo, Kyriaki Michailidou… in Nature Genetics (2018)

  2. No Access

    Article

    Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

    Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants an...

    Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou… in Nature Genetics (2017)

  3. No Access

    Article

    Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

    John Perry, Ken Ong and colleagues analyze genotype data on ∼370,000 women and identify 389 independent signals that associate with age at menarche, implicating ∼250 genes. Their analyses suggest causal invers...

    Felix R Day, Deborah J Thompson, Hannes Helgason, Daniel I Chasman… in Nature Genetics (2017)

  4. No Access

    Article

    Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

    John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enri...

    Felix R Day, Katherine S Ruth, Deborah J Thompson, Kathryn L Lunetta… in Nature Genetics (2015)

  5. No Access

    Article

    Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Doug Easton and colleagues report the results of a large-scale genome-wide association study of breast cancer. They discover 15 new susceptibility loci and highlight likely target genes in several of the newly...

    Kyriaki Michailidou, Jonathan Beesley, Sara Lindstrom, Sander Canisius… in Nature Genetics (2015)

  6. No Access

    Article

    Genome-wide association studies identify four ER negative–specific breast cancer risk loci

    Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35...

    Montserrat Garcia-Closas, Fergus J Couch, Sara Lindstrom… in Nature Genetics (2013)

  7. No Access

    Article

    Large-scale genoty** identifies 41 new loci associated with breast cancer risk

    Douglas Easton, Per Hall and colleagues report meta-analyses of genome-wide association studies for breast cancer, including 10,052 cases and 12,575 controls, followed by genoty** using the iCOGS array in an...

    Kyriaki Michailidou, Per Hall, Anna Gonzalez-Neira, Maya Ghoussaini… in Nature Genetics (2013)

  8. No Access

    Article

    Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations ...

    Stig E Bojesen, Karen A Pooley, Sharon E Johnatty, Jonathan Beesley… in Nature Genetics (2013)

  9. No Access

    Article

    Genome-wide association analysis identifies three new breast cancer susceptibility loci

    Douglas Easton and colleagues report a genome-wide association analyses for breast cancer in ~70,000 cases and ~68,000 controls. They identify three new breast cancer susceptibility loci, two of which show ass...

    Maya Ghoussaini, Olivia Fletcher, Kyriaki Michailidou, Clare Turnbull… in Nature Genetics (2012)

  10. No Access

    Article

    A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

    Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L lo...

    Christopher A Haiman, Gary K Chen, Celine M Vachon, Federico Canzian… in Nature Genetics (2011)

  11. No Access

    Article

    A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

    Fergus Couch and colleagues report a genome-wide association study for modifiers of breast cancer susceptibility in BRCA1 mutation carriers. They identify a locus at 19p13 associated with breast cancer risk in BR...

    Antonis C Antoniou, **anshu Wang, Zachary S Fredericksen… in Nature Genetics (2010)