20 Result(s)
within
English
Life Sciences
Life Sciences, general
Deyu **n
Article
-
Article
Open AccessGenome assembly of M. spongiola and comparative genomics of the genus Morchella provide initial insights into taxonomy and adaptive evolution
Morchella spongiola is a highly prized mushroom for its delicious flavor and medical value and is one of the most flourishing, representative, and dominant macrofungi in the Qilian Mountains of the Qinghai-Tibet ...
-
Article
Open AccessDe novo and somatic structural variant discovery with SVision-pro
Long-read-based de novo and somatic structural variant (SV) discovery remains challenging, necessitating genomic comparison between samples. We developed SVision-pro, a neural-network-based instance segmentati...
-
Article
Open AccessIntegrated analysis of the ubiquitination mechanism reveals the specific signatures of tissue and cancer
Ubiquitination controls almost all cellular processes. The dysregulation of ubiquitination signals is closely associated with the initiation and progression of multiple diseases. However, there is little compr...
-
Article
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity
cGAS/DncV-like nucleotidyltransferase (CD-NTase) family members are immune sensors that synthesize diverse nucleotide signals to initiate antiviral response in bacteria and animals. As a founding member of CD-...
-
Article
Open AccessHepatocyte growth factor-mediated apoptosis mechanisms of cytotoxic CD8+ T cells in normal and cirrhotic livers
Intrahepatic stem/progenitor cells and cytotoxic CD8+ T cells (CD8+ T cells) in the cirrhotic liver undergo apoptosis, which potentially facilitates progression to cancer. Here, we report that hepatocyte growth f...
-
Article
Open AccessCorrection to: DC-SIGN–LEF1/TCF1–miR-185 feedback loop promotes colorectal cancer invasion and metastasis
A Correction to this paper has been published: https://doi.org/10.1038/s41418-021-00736-9
-
Article
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2
The severity and mortality of COVID-19 are associated with pre-existing medical comorbidities such as diabetes mellitus. However, the underlying causes for increased susceptibility to viral infection in patien...
-
Article
Open AccessFerroptosis-associated DNA methylation signature predicts overall survival in patients with head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a common cancer characterized by late diagnosis and poor prognosis. The aim of this study was to identify a novel ferroptosis-related DNA methylation signature ...
-
Article
Open AccessAvibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro
Treatment options for Stenotrophomonas maltophilia (S. maltophilia) infections were limited. We assessed the efficacy of ceftazidime (CAZ), ceftazidime-avibactam (CAZ-AVI), aztreonam (ATM), and aztreonam-avibacta...
-
Article
Open AccessComparative transcriptomics of stem bark reveals genes associated with bast fiber development in Boehmeria nivea L. gaud (ramie)
Boehmeria nivea L. Gaud (Ramie) produces one of the longest natural fibers in nature. The bark of ramie mainly comprises of the phloem tissue of stem and is the raw material for fiber. Therefore, identifying the ...
-
Article
Open AccessDC-SIGN–LEF1/TCF1–miR-185 feedback loop promotes colorectal cancer invasion and metastasis
DC-SIGN is previously focused on its physiologic and pathophysiologic roles in immune cells. Little is known about whether DC-SIGN is expressed in malignant epithelial cells and how DC-SIGN participates in tum...
-
Article
Open AccessMicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma
Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has b...
-
Article
PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix
Biofilms are surface-associated communities of microorganism embedded in extracellular matrix. Exopolysaccharide is a critical component in the extracellular matrix that maintains biofilm architecture and prot...
-
Article
Open AccessUbiquitin-specific protease 22 is a deubiquitinase of CCNB1
The elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discove...
-
Article
Open AccessA novel ER–microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression
The gene encoding endoplasmic reticulum (ER) lipid raft-associated protein 2 (ERLIN2) is amplified in human breast cancers. ERLIN2 gene mutations were also found to be associated with human childhood progressive ...
-
Article
Open AccessDetermination of delay time in individual transfer function for central aortic pressure reconstruction
In previous research, time-delay (Δt) was a more important parameter than the reflection coefficient in the individual transfer function of central aortic pressure reconstruction. The Δt can be obtained by electr...
-
Article
Open AccessRelationship between triphasic mechanical properties of articular cartilage and osteoarthritic grade
The purpose of this study was to explore the triphasic mechanical properties of osteoarthritic cartilage with different pathological grades. First, samples of cartilage from rabbits with different stages of os...
-
Article
Open AccessUltrasound speed and attenuation in progressive trypsin digested articular cartilage
Subtle changes of articular cartilage (AC) can lead to tissue degeneration and even osteoarthritis (OA). The early degeneration of AC is closely related to a change in proteoglycans (PG) content. The observati...
-
Article
Open AccessVesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form
Aggregatibacter actinomycetemcomitans is an oral bacterium associated with aggressively progressing periodontitis. Extracellular release of bacterial outer membrane proteins has been suggested to mainly occur via...
-
Article
Whole-virus Vaccine Development by Continuous Culture on a Complementing Host
We have evaluated an adaptive strategy for generating whole-virus vaccines using a bacteriophage model. Wildtype phage T7 was cultivated in a two-stage continuous stirred-tank reactor (CSTR) utilizing a recomb...
