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    High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population

    The discovery of the highly efficient site-specific nuclease system CRISPR–Cas9 from Streptococcus pyogenes has galvanized the field of gene therapy1,2. The immunogenicity of Cas9 nuclease has been demonstrated i...

    Dimitrios L. Wagner, Leila Amini, Desiree J. Wendering in Nature Medicine (2019)