16 Result(s)
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Article
David A. Harris
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Open AccessNew role of fat-free mass in cancer risk linked with genetic predisposition
Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a r...
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Mechanisms of prion-induced toxicity
Prion diseases are devastating neurodegenerative diseases caused by the structural conversion of the normally benign prion protein (PrPC) to an infectious, disease-associated, conformer, PrPSc. After decades of i...
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Open AccessObesity: a perfect storm for carcinogenesis
Obesity-related cancers account for 40% of the cancer cases observed in the USA and obesity is overtaking smoking as the most widespread modifiable risk factor for carcinogenesis. Here, we use the hallmarks of...
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Open AccessAβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
Several cell-surface receptors for neurotoxic forms of amyloid-β (Aβ) have been described, but their molecular interactions with Aβ assemblies and their relative contributions to mediating Alzheimer’s disease ...
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Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated with increased levels of the incretin hormone glucagon-like peptide-1 (GLP-1) and changes in levels of circulating...
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Open AccessPrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Neurodegenerative diseases are an enormous public health problem, affecting tens of millions of people worldwide. Nearly all of these diseases are characterized by oligomerization and fibrillization of neurona...
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Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Attenuate Pro-inflammatory Small Intestinal Cytokine Signatures
Bariatric surgery rapidly induces improvements in type 2 diabetes (T2D) in concert with reduction in systemic markers of inflammation. The impact of bariatric surgery on local intestinal immunity is not known....
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Association of Bariatric Surgery Status with Reduced HER2+ Breast Cancers: a Retrospective Cohort Study
Bariatric surgery is associated with a reduced risk of develo** certain malignancies, particularly in women. However, the impact of bariatric surgery on tumor characteristics, cancer treatment, and oncologic...
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Open AccessActivation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo
Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-depe...
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Ectopic F0F1 ATP synthase contains both nuclear and mitochondrially-encoded subunits
Over the past few years, several reports have described the presence of F0F1 ATP synthase subunits at the surface of hepatocytes, where the hydrolytic activity of F1 sector faces outside and triggers HDL endocyto...
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The ectopic FOF1 ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1
Rat liver plasma membranes contain FOF1 complexes (ecto-FOF1) displaying a similar molecular weight to the mitochondrial FOF1 ATP synthase, as evidenced by Blue Native PAGE. Their ATPase activity was stably reduc...
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Open AccessPrion protein lacks robust cytoprotective activity in cultured cells
The physiological function of the cellular prion protein (PrPC) remains unknown. However, PrPC has been reported to possess a cytoprotective activity that prevents death of neurons and other cells after a toxic s...
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U.S. experiences with racial and ethnic profiling: history, current issues, and the future
The issue of racial and ethnic bias in policing has been the focus of legal and criminal justice scholarship, court action, and public debate in the U.S. for a number of years. The issue has also been prominen...
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Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor
A glycoprotein purified from chick brain, of relative molecular mass 42,000, increases the rate of appearance of acetylcholine receptors (AChRs) on the surface of chick myotubes1. RNase protection assays have sho...
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SOMATOMEDIN-C (SM) LEVELS IN PATIENTS WITH TRUE PRECOCIOUS PUBERTY: EFFECT OF TREATMENT WITH A POTENT LRF-AGONIST (LRF-A)
An interrelationship has been suggested between SM, growth rate, and sex steroid levels in normal puberty. We measured serum acid-ethanol extractable SM by RIA in 7 boys and 12 girls with central precocious pu...
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Binding of mitochondrial ATPase from ox heart to its naturally occurring inhibitor protein: Localization by antibody binding
The naturally occurring ATPase inhibitor protein from ox heart mitochondria was cross-linked to its binding site on the mitochondrial ATPase using 1-ethyl-3-(dimethylamino)propyl carbodiimide. The cross-linked...
