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Article
Gender differences in doxorubicin pharmacology for subjects with chemosensitive cancers of young adulthood
For many cancers, adolescents and young adults (AYA) have worse outcomes than for children and adults. Many factors may contribute to the AYA survival gap, including differences in biology, therapeutic intent,...
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Article
Open AccessCorrection to: Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel
The original article contains several small errors. The errors & concurrent corrections are listed below [1]:
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Article
Effect of obesity on aromatase inhibitor efficacy in postmenopausal, hormone receptor-positive breast cancer: a systematic review
Aromatase inhibitors (AIs) decrease the production of oestrogen, decreasing stimulation of hormone receptor-positive breast cancer. Theoretically, AIs may be less effective in obese women, due to the greater q...
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Article
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations
Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once metastatic there is no effective treatment currently available. Eighty percent of UMs harbor mutations in the Gαq family m...
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Article
Erratum: Smac mimetics: implications for enhancement of targeted therapies in leukemia
Correction to: Leukemia (2010) 25, 2100–2109; doi:10.1038/leu.2010.212 Owing to a typesetting error, the following sentence was incorrectly printed in the abstract section of the article: ‘The novel inhibitor ...
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Article
Smac mimetics: implications for enhancement of targeted therapies in leukemia
Drug resistance is a growing concern with clinical use of tyrosine kinase inhibitors. Utilizing in vitro models of intrinsic drug resistance and stromal-mediated chemoresistance, as well as functional mouse model...
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Article
HIN-1, an inhibitor of cell growth, invasion, and AKT1 activation
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Article
Open AccessPhenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbiditi...
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Article
Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive progressive multifocal leukoencephalopathy
Nonmyeloablative allogeneic stem cell transplantation (NMASCT) can be used to exploit the graft-versus-tumor (GVT) potential of allogeneic donor cells in the setting of reduced conditioning regimen toxicity. ...
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Article
Constitutional p53 mutation in a non-Li-Fraumeni cancer family