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  1. Article

    Open Access

    Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

    The mitochondrial translation machinery highly diverged from its bacterial counterpart. This includes deviation from the universal genetic code, with AGA and AGG codons lacking cognate tRNAs in human mitochond...

    Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev in Nature Communications (2023)

  2. Article

    Open Access

    Distinct pre-initiation steps in human mitochondrial translation

    Translation initiation in human mitochondria relies upon specialized mitoribosomes and initiation factors, mtIF2 and mtIF3, which have diverged from their bacterial counterparts. Here we report two distinct mi...

    Anas Khawaja, Yuzuru Itoh, Cristina Remes, Henrik Spåhr in Nature Communications (2020)

  3. Article

    Open Access

    A Novel Method to Evaluate Ribosomal Performance in Cell-Free Protein Synthesis Systems

    Cell-free protein synthesis (CFPS) systems were designed to produce proteins with a minimal set of purified components, thus offering the possibility to follow translation as well as protein folding. In order ...

    Noémie Kempf, Cristina Remes, Ralph Ledesch, Tina Züchner in Scientific Reports (2017)