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  1. Article

    Open Access

    Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study

    Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...

    Hui-Jen Tsai, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai… in BMC Cancer (2024)

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  2. Article

    Open Access

    Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy

    The impact of KRAS signaling on cancerous inhibitor of protein phosphatase 2A (CIP2A) expression has not yet been explored. We investigated the impact of KRAS on CIP2A expression in colorectal cancer patients ...

    Kuen-Feng Chen, Chueh-Chuan Yen, Jen-Kou Lin, Wei-Shone Chen, Shung-Haur Yang… in BMC Cancer (2015)

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  3. No Access

    Article

    Comparison of cetuximab to bevacizumab as the first-line bio-chemotherapy for patients with metastatic colorectal cancer: Superior progression-free survival is restricted to patients with measurable tumors and objective tumor response—a retrospective study

    We aimed to compare the treatment efficacy of cetuximab versus bevacizumab in combination with either irinotecan-based or oxaliplatin-based regimens (targeted triplet) as the first-line treatment for patients...

    Yuan-Hao Yang, Jen-Kou Lin, Wei-Shone Chen… in Journal of Cancer Research and Clinical On… (2014)

  4. No Access

    Article

    Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism

    A dozen clinical trials examining a combination of temsirolimus and cetuximab in treating metastatic colon cancer are currently underway. We investigated the role of cancerous inhibitor of protein phosphatase ...

    Hsei-Wei Wang, Shung-Haur Yang… in Journal of Cancer Research and Clinical On… (2014)

  5. No Access

    Article

    Duloxetine improves oxaliplatin-induced neuropathy in patients with colorectal cancer: an open-label pilot study

    This open-label pilot study is aimed to evaluate the efficacy and tolerability of the antidepressant duloxetine, which is effective for diabetic neuropathic pain, in the treatment of chronic oxaliplatin-induce...

    Ya-Hsu Yang, Jen-Kou Lin, Wei-Shone Chen, Tzu-Chen Lin… in Supportive Care in Cancer (2012)

  6. No Access

    Article

    Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin’s lymphoma: the single-institute experience in Taiwan

    Primary pulmonary lymphoma (PPL) accounts for less than 1% of patients with non-Hodgkin’s lymphoma, with no report in Chinese patients. This study aims to analyze the clinical features and prognosis of this po...

    Yu-Hui Hu, Liang-Tsai Hsiao, Ching-Fen Yang, Tzeon-Jye Chiou… in Annals of Hematology (2009)

  7. No Access

    Article

    High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma

    Several reports recently found that patients with B cell non-Hodgkin’s lymphoma (NHL) had a higher carrier rate of hepatitis B surface antigen (HBsAg). The current study aimed to examine the hepatitis B virus ...

    Ming-Huang Chen, Liang-Tsai Hsiao, Tzeon-Jye Chiou, **-Hwang Liu… in Annals of Hematology (2008)

  8. No Access

    Article

    Rituximab therapy increased post-transplant cytomegalovirus complications in Non-Hodgkin’s lymphoma patients receiving autologous hematopoietic stem cell transplantation

    The use of monoclonal antibody, rituximab, had been reported to be associated with some severe viral infections. The inference of rituximab therapy and post-transplant cytomegalovirus (CMV) infectious complica...

    Ming-Yang Lee, Tzeon-Jye Chiou, Liang-Tsai Hsiao, Muh-Hwa Yang… in Annals of Hematology (2008)

  9. No Access

    Article

    Higher fungal infection rate in elderly patients (more than 80 years old) suffering from diffuse large B cell lymphoma and treated with rituximab plus CHOP

    Although adding rituximab to standard cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy is an efficacious and well-tolerated regimen in elderly patients with diffuse large B cell l...

    Peng-Chan Lin, Liang-Tsai Hsiao, Say-Bee Poh, Wei-Shu Wang… in Annals of Hematology (2007)

  10. No Access

    Article

    Severe anaphylactic reactions in patients receiving oxaliplatin therapy: a rare but potentially fatal complication

    The most well-known adverse events of oxaliplatin are hematologic toxicity, gastrointestinal tract toxicity, and sensory neuropathy. However, hypersensitivity reaction of oxaliplatin, especially severe anaphyl...

    Ming-Yang Lee, Muh-Hwa Yang, **-Hwang Liu, Chueh-Chuan Yen… in Supportive Care in Cancer (2007)

  11. No Access

    Article

    N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: preliminary data

    Although adding oxaliplatin to fluorouracil and leucovorin in adjuvant chemotherapy for colon cancer may improve disease-free survival, grade 3–4 sensory neuropathy also increases. To determine whether oral N-ace...

    Peng-Chan Lin, Ming-Yang Lee, Wei-Shu Wang, Chueh-Chuan Yen… in Supportive Care in Cancer (2006)