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Article
Comparative Analysis of Different Puberty Inhibiting Mechanisms of Two GnRH Agonists and the GnRH Antagonist Cetrorelix Using a Female Rat Model
GnRH agonists are the established treatment of precocious puberty caused by premature stimulation of gonadotropin secretion. It has been reported that after an initial stimulation (“flare-up”) they reduce LH s...
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Article
Open AccessIntrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma
Data on sequential therapy in patients with metastatic renal cell carcinoma (mRCC) and intrinsic resistance to receptor tyrosine kinase inhibitor (rTKI) treatment remains vague.
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Article
Open AccessImatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST)
The use of imatinib mesylate is associated with a progression free survival of 41 months in first line treatment of metastatic or locally advanced gastrointestinal stromal tumors (GIST) and other studies appro...
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Article
Open AccessValidation of CRP as prognostic marker for renal cell carcinoma in a large series of patients
To evaluate the prognostic significance of the pre-operative C-reactive protein (CRP) serum level in patients with renal cell cancer (RCC).
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Article
Open AccessPreoperative serum C- reactive protein: a prognostic marker in patients with upper urinary tract urothelial carcinoma
To analyse the prognostic significance of preoperative C-reactive protein (CRP) serum level in patients with upper urinary tract urothelial carcinoma (UUT-UC).
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Article
Serum C-reactive protein: a prognostic factor in metastatic urothelial cancer of the bladder
Until today, there is no reliable prognostic or predictive parameter for the prognosis of patients with metastatic urothelial cancer of the bladder prior to chemotherapy. Recently, serum C-reactive protein (CR...
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Article
Cisplatin-refraktäre Keimzelltumoren
Trotz der im Allgemeinen exzellenten Heilungsaussichten für Keimzelltumorpatienten sind Patienten mit Cisplatin-refraktärer Erkrankung weiterhin mit einer sehr ungünstigen Prognose konfrontiert.
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Article
Retinal toxicity after cisplatin-based chemotherapy in patients with germ cell cancer
Visual impairment represents an infrequent form of cisplatin-induced neurotoxicity; however, visual deterioration has been reported in several studies. To evaluate potential morphological and functional retina...
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Article
Treatment of refractory germ-cell tumours with single-agent cabazitaxel: a German Testicular Cancer Study Group case series
Outcomes of multiply relapsed, refractory germ-cell tumour (GCT) patients remain poor with an overall survival (OS) of a few months only. Thus, new therapeutic advances are urgently needed. Cabazitaxel has sho...
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Article
Thromboembolische Komplikationen und Thromboseprophylaxe bei fortgeschrittenen testikulären Keimzelltumoren
Testikuläre Keimzelltumoren (TGCT) stellen die häufigste Neoplasie des jungen Mannes dar. Die hohen Ansprechraten auf eine cisplatinbasierte Chemotherapie führt bei diesen Tumoren selbst in metastasierten Stad...
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Article
Primär mediastinale Keimzelltumoren – eine interdisziplinäre Herausforderung
Primär mediastinale Keimzelltumoren entstehen im vorderen Mediastinum. Sie sind histologisch mit männlichen Keimzelltumoren des Hodens identisch, weisen aber eine distinkte Biologie und eine schlechtere Progno...
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Article
Open AccessThe prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)
The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and ot...
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Article
Open AccessPeritoneal carcinosis in male germ cell tumor patients: a registry study compiled by the German Testicular Cancer Study Group (GTCSG)
To report on the clinical characteristics, outcome, and frequency of peritoneal carcinosis (PC) in patients with advanced germ cell tumors (GCT), a multicenter registry analysis was carried out.
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Article
Open AccessApproaches of stem cell mobilization in a large cohort of metastatic germ cell cancer patients
High-dose chemotherapy (HD-Cx) in refractory germ cell cancer (GCC) is effective but limited data are available concerning the optimal approach for stem cell mobilization (SCM) in these patients. In this analy...
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Article
Multimodale Therapie des Hodentumors: wann Chemotherapie, Operation oder Strahlentherapie?
Um optimale Therapieergebnisse zu erzielen sind metastasierte Hodentumorpatienten auf eine histologie- und stadienadaptierte Therapie angewiesen.
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Article
Open AccessMolecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum
Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component...
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Article
Open AccessLong-term cardiotoxicity in germ cell cancer survivors after platinum-based chemotherapy: cardiac MR shows impaired systolic function and tissue alterations
Long-term toxicities of germ cell cancer (GCC) treatment are of particular importance in young men with a life expectancy of several decades after curative treatment. This study aimed to investigate the long-t...
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Article
Open AccessMultidisciplinary survey on use of feeding tubes in head and neck cancer patients undergoing chemoradiotherapy in Germany—the SUFEETUBE project
Data on enteral tube feeding in head and neck cancer (HNC) patients undergoing chemoradiotherapy vary considerably between German institutions. This survey aims to investigate the management of feeding tubes i...