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  1. Article

    Open Access

    Machine learning application for the prediction of SARS-CoV-2 infection using blood tests and chest radiograph

    Triaging and prioritising patients for RT-PCR test had been essential in the management of COVID-19 in resource-scarce countries. In this study, we applied machine learning (ML) to the task of detection of SAR...

    Richard Du, Efstratios D. Tsougenis, Joshua W. K. Ho in Scientific Reports (2021)

  2. Article

    Open Access

    To drain or not to drain: the association between residual intraperitoneal gas and post-laparoscopic shoulder pain for laparoscopic cholecystectomy

    Residual intra-peritoneal gas may be associated with post-laparoscopic shoulder pain (PLSP), which is a frequently and disturbance compliant after surgery. Herein, we aimed to examine whether expiring residual...

    Shun-Chin Yang, Kuang-Yi Chang, Ling-Fang Wei, Yi-Ming Shyr in Scientific Reports (2021)

  3. Article

    Open Access

    Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes

    We hypothesized that epigenetics is a link between smoking/allergen exposures and the development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of 228 COPD patients were identified a...

    Yung-Che Chen, Ying-Huang Tsai, Chin-Chou Wang, Shih-Feng Liu in Scientific Reports (2021)

  4. Article

    Open Access

    Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death

    Few studies quantify a cascade of dynamic transitions on the detailed components of metabolic syndrome (MetS) and subsequent progressions to cardiovascular disease (CVD) and its death. A total of 47,495 subjec...

    Ting-Yu Lin, Kuo-Liong Chien, Yueh-Hsia Chiu, Pi-Chun Chuang in Scientific Reports (2021)

  5. Article

    Open Access

    Association between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients

    The association between regional economic status and the probability of renal recovery among patients with dialysis-requiring AKI (AKI-D) is unknown. The nationwide prospective multicenter study enrolled criti...

    Chih-Chung Shiao, Yu-Hsing Chang, Ya-Fei Yang, En-Tzu Lin in Scientific Reports (2020)

  6. Article

    Open Access

    A reporter mouse for non-invasive detection of toll-like receptor ligands induced acute phase responses

    The acute phase response (APR) is a systemic first-line defense against challenges including infection, trauma, stress, and neoplasia. Alteration of acute phase protein (APP) levels in plasma is the most impor...

    Chun-Fang Huang, Shang-Yi Chiu, Hung-Wen Huang, Bing-Ho Cheng in Scientific Reports (2019)

  7. Article

    Open Access

    A randomized feasibility study of the effect of ascorbic acid on post-angioplasty restenosis of hemodialysis vascular access (NCT03524846)

    Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty resten...

    Chung-Wei Yang, Chih-Cheng Wu, Chien-Ming Luo, Shao-Yuan Chuang in Scientific Reports (2019)

  8. Article

    Open Access

    Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese

    The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the assoc...

    Tzy-Haw Wu, Jean Ching-Yuan Fann, Sam Li-Sheng Chen in Scientific Reports (2018)

  9. Article

    Open Access

    Gene–physical activity interactions in lower extremity performance: inflammatory genes CRP, TNF-α, and LTA in community-dwelling elders

    We assessed gene–gene and gene-physical activity interactions of polymorphisms in C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and lymphotoxin α (LTA) genes on lower extremity performance in comm...

    Chiu-Shong Liu, Tsai-Chung Li, Chia-Ing Li, Li-Na Liao in Scientific Reports (2017)

  10. Article

    Open Access

    Duration of untreated bipolar disorder: a multicenter study

    Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features...

    Ling Zhang, **n Yu, Yi-Ru Fang, Gabor S. Ungvari, Chee H. Ng in Scientific Reports (2017)

  11. Article

    Open Access

    Comorbid diseases as risk factors for incident posttraumatic stress disorder (PTSD) in a large community cohort (KCIS no.PSY4)

    Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general populatio...

    Jung-Chen Chang, Amy Ming-Fang Yen, Hsiu-Hsi Chen, Sam Li-Sheng Chen in Scientific Reports (2017)