18 Result(s)
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Article
Chitra Joseph
Oncology
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Article
Open AccessPhenotypic characterisation of breast cancer: the role of CDC42
The molecular landscape of breast cancer (BC), especially of the Luminal A subtype, remains to be fully delineated. Transcriptomic data show that Luminal A tumours are enriched for aberrant expression of genes...
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Open AccessMediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes
Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovas...
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Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis
The functions of many proteins are tightly regulated with a complex array of cellular functions including ubiquitination. In cancer cells, aberrant ubiquitination may promote the activity of oncogenic pathways...
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Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer
Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re-epithelialisation in invasive carcinoma and, therefore, may play a key role in carcinogenesis and metasta...
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Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer
CD133/ prominin 1 is a cancer stem cell marker associated with cancer progression and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) remains obscure. The current stu...
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Open AccessA key genomic subtype associated with lymphovascular invasion in invasive breast cancer
Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, rem...
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Utility of ankyrin 3 as a prognostic marker in androgen-receptor-positive breast cancer
Androgen receptor (AR) and AR signaling pathways are thought to play a role in breast cancer (BC) and are potentially related to treatment responses and outcomes. Ankyrin 3 (ANK3) is associated with AR stabili...
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Open AccessRetinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer
Retinoid X Receptor Gamma (RXRG) is a member of the nuclear receptor superfamily and plays a role in tumour suppression. This study aims to explore the prognostic significance of RXRG in breast cancer.
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Open AccessPrognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer
KN motif and ankyrin repeat domains 1 (KANK1) plays an important role in cytoskeleton maintenance and contributes to the regulation of cell proliferation, adhesion and apoptosis. KANK1 is involved in progressi...
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Open AccessThe prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild-type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explor...
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Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer
The epithelial–mesenchymal transition (EMT) plays a key role in breast cancer progression and metastasis. Lipocalin 2 (LCN2) is involved in the regulation of EMT. The aim of this study was to investigate the c...
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Open AccessThe prognostic significance of immune microenvironment in breast ductal carcinoma in situ
The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lym...
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Open AccessMyxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer
Breast cancer (BC) is a disease with variable morphology, clinical behaviour and response to therapy. Identifying factors associated with the progression of early-stage BC can help understand the risk of metas...
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Open AccessElevated MMP9 expression in breast cancer is a predictor of shorter patient survival
MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion molecules and cytokines. This study aims to...
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Open AccessThe prognostic significance of BMI1 expression in invasive breast cancer is dependent on its molecular subtypes
BMI1, which is a major component of the polycomb group complex 1, is an essential epigenetic repressor of multiple regulatory genes and has been identified as a cancer stem cell (CSC) marker in several cancers...
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Open AccessThe prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer
Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed the positive association between interfero...
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Open AccessOestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer
The outcome of the luminal oestrogen receptor-positive (ER +) subtype of breast cancer (BC) is highly variable and patient stratification needs to be refined. We assessed the prognostic significance of oestrog...
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Open AccessUbiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer
The Ubiquitin-conjugating enzyme 2C (UBE2C) is essential for the ubiquitin–proteasome system and is involved in cancer cell migration and apoptosis. This study aimed to determine the prognostic value of UBE2C ...
