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    A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos

    During mammalian early embryogenesis, expression and epigenetic heterogeneity emerge before the first cell fate determination, but the programs causing such determinate heterogeneity are largely unexplored.

    Chengchen Zhao, Naiqian Zhang, Yalin Zhang, Nuermaimaiti Tuersunjiang… in Genome Biology (2020)

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