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Article
Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography
Enhancer of zeste homolog 2 (EZH2) is responsible for the methylation of lysine 27 of histone H3 (H3K27) leading to transcriptional repression. Consequently, EZH2 is related with several diseases including can...
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Article
Synthesis of a carbon-11 radiolabeled BACE1 inhibitor
Beta-secretase (BACE1), a transmembrane aspartyl protease, can cleave membrane-bound β-amyloid precursor proteins (APPs) to initiate the accumulation of amyloid-β (Aβ). The inhibition of BACE-1 to limit the ac...