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Article
Ecosystem health assessment on the hill and gully area of loess Plateau in Inner Mongolia, China
Maintenance of ecosystem health is the primary focus of a sound ecological restoration. Yet methods involved in quantifying and assessing the health level remain a challenge to the ecological community. In thi...
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Article
Cloning and developmental expression of the Xenopus Nkx6 genes
The evolutionarily conserved Nkx6 family transcription factors play important roles in the patterning of the central nervous system (CNS) and pancreas in vertebrates. In this study, we describe the cloning and ex...
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Article
The Selection of Recombinant Binary Plasmids Generated by Gateway® LR Cloning in the Escherichia coli Strain C2110
Gateway® cloning is widely used in molecular biology laboratories. Various binary vectors used for Agrobacterium-mediated plant transformation have been modified as destination vectors that are convenient for the...
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Article
Xenopus Nkx6.1 and Nkx6.2 are required for mid–hindbrain boundary development
The mid-hindbrain boundary (MHB) organizer is among the best studied local organizers that patterns the midbrain and cerebellum in vertebrates and is established by a regulatory network of several transcriptio...
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Article
Open AccessThe transcriptional network of WRKY53 in cereals links oxidative responses to biotic and abiotic stress inputs
The transcription factor WRKY53 is expressed during biotic and abiotic stress responses in cereals, but little is currently known about its regulation, structure and downstream targets. We sequenced the wheat ort...
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Article
Open AccessA possible role of Drosophila CTCF in mitotic bookmarking and maintaining chromatin domains during the cell cycle
The CCCTC-binding factor (CTCF) is a highly conserved insulator protein that plays various roles in many cellular processes. CTCF is one of the main architecture proteins in higher eukaryotes, and in combinati...
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Article
Overexpression of the novel Zygophyllum xanthoxylum C2H2-type zinc finger gene ZxZF improves drought tolerance in transgenic Arabidopsis and poplar
Zygophyllum xanthoxylum (Bunge) is a perennial woody succulent xerophyte that is one of the most droughttolerant plant species identified to date. In this study, the gene encoding the novel C2H2-type zinc finger ...
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Article
Open AccessExosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure
Human menstrual blood-derived stem cells (MenSCs) are a novel source of MSCs that provide the advantage of being easy to collect and isolate. Exosomes contain some mRNAs and adhesion molecules that can potenti...
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Article
Open AccessAlcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells
Both alcohol and hepatitis C virus (HCV) infection could induce cellular autophagy in liver cells, which is considered to be essential for productive HCV replication. However, whether alcohol-induced autophagy...
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Article
Transcriptome analysis of Cd-treated switchgrass root revealed novel transcripts and the importance of HSF/HSP network in switchgrass Cd tolerance
Transcriptome analysis of Cd-treated switchgrass roots not only revealed novel switchgrass transcripts and gene structures but also highlighted the indispensable role of HSF/HSP network in switchgrass Cd toler...
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Article
Open AccessMesenchymal stem cell transplantation ameliorates Sjögren’s syndrome via suppressing IL-12 production by dendritic cells
Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren’s syndrome (SS). We aim to compare the effects of MSC transplantation (MSCT) and the role ...
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Article
MicroRNA-214 targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell apoptosis
Cardiovascular disease (CVD) serves as the major cause of mortality in chronic kidney disease (CKD) patients. The injury of endothelium associated with the long-term challenge of uremic toxins including the to...
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Article
Open AccessSatb2 is required for the regionalization of retrosplenial cortex
The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from the archicortex remains elusive. We here report that the t...
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Article
Open AccessEmerging role of the Hippo pathway in autophagy
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromol...
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Article
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense
STAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated and activated upon IFN signaling remain...
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Article
Production of an epigenetic mutant population of Populus nigra: DNA methylation and phenotype analyses
5-Azacytidine (5-AzaC) causes hypomethylation of genomic DNA and induces phenotype variation in many plant species. Modulating the methylation status of cytosine by 5-AzaC to generate novel phenotypes in popla...
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Open AccessHigh stearic acid diet modulates gut microbiota and aggravates acute graft-versus-host disease
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Article
Open AccessTRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly u...
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Article
Open AccessSatb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1
Dopaminergic (DA) neurons in the arcuate nucleus (ARC) of the hypothalamus play essential roles in the secretion of prolactin and the regulation of energy homeostasis. However, the gene regulatory network resp...
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Article
Open AccessThe overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation
Aging is a natural and progressive process characterized by an increased frequency of age-related diseases such as cancer. But its mechanism is unclear. TNFAIP8L2 (Tipe2) is an important negative regulator for...