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Article
Changes in Human Mucosal γδ T Cell Repertoire and Function Associated with the Disease Process in Inflammatory Bowel Disease
Although γδ T cells are a major component of the human intestinal mucosa, it is not clear what role they play in mucosal immunity or if they are involved in the disease process of inflammatory bowel disease (IBD)...
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Article
Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis
Although it has been known that γδ T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis (M. tb), the mechanisms by which the γδ T cells participate in the innate an...
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Article
Quantum chemistry studies of the catalysis mechanism differences between the two isoforms of glutamic acid decarboxylase
The production of gamma-aminobutyric acid (GABA) is catalyzed by two isoforms of glutamic acid decarboxylase (GAD), using pyridoxal 5′-phosphate (PLP) as the cofactor. Between the two enzymes, GAD67 accounts f...
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Article
Open AccessRegulating reserve with large penetration of renewable energy using midterm dynamic simulation
A novel renewable energy intermittency model and a new midterm dynamic simulation tool in power systems are developed for examining dynamic behavior along the load curve for different combinations of the syste...
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Article
Mycobacterium Tuberculosis-Specific Memory NKT Cells in Patients with Tuberculous Pleurisy
Natural killer T (NKT) cells from mouse and human play a protective role in the immune responses against the infection of Mycobacterium tuberculosis. However, the characteristic of CD3+TCRvβ11+ NKT cells at the l...
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Article
Reaction mechanism of organoselenium-catalyzed syn-dichlorination of alkenes: a DFT study
A new method for the syn-dichlorination of alkenes at room temperature has been proposed by Denmark et al. The method uses diselenide (PhSeSePh) as the precatalyst, benzyltriethylammonium chloride (BnEt3NCl) as t...
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Article
Patients with systemic lupus erythematosus show increased proportions of CD19+CD20− B cells and secretion of related autoantibodies
At present, anti-CD20 monoclonal antibody treatments targeting systemic lupus erythematosus (SLE) are complex, variable, and often have disappointing outcomes. High levels of programmed cell death-1 (PD-1) and...
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Article
Orlistat induces ferroptosis-like cell death of lung cancer cells
Aberrant de novo lipid synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an ...
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Article
Open AccessA deep learning framework for accurate reaction prediction and its application on high-throughput experimentation data
In recent years, it has been seen that artificial intelligence (AI) starts to bring revolutionary changes to chemical synthesis. However, the lack of suitable ways of representing chemical reactions and the sc...
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Article
Open AccessThe effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic lupus erythematosus
The defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a key role in the occurrence and development of systemic lupus erythemat...
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Article
Open AccessAnalysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function
Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) is a peptide antigen released from the mycobacterial cytoplasm into the supernatant of Mycobacterium tuberculosis (Mtb) attenuated H37Ra strain after au...
