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Article
Vascular safety during arthroscopic all-inside meniscus suture
The purpose of the study is to assess the orientation and distance of the popliteal artery (PA) from both the anteromedial and anterolateral portals.
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Article
Elevated soluble platelet glycoprotein VI is a useful marker for DVT in postoperative patients treated with edoxaban
Prevention of deep vein thrombosis (DVT) is important in patients undergoing major orthopedic surgery. Although the detection of an elevated d-dimer level is useful for predicting DVT, it is not efficacious in p...
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Article
Clinical outcomes of Kyocera Modular Limb Salvage system after resection of bone sarcoma of the distal part of the femur: the Japanese Musculoskeletal Oncology Group study
The Japanese Musculoskeletal Oncology Group have developed an original prosthesis called the Kyocera Modular Limb Salvage system (KMLS system). This prosthesis has a semi-rotating hinge joint and is particular...
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Article
Prevalence of hallux valgus and risk factors among Japanese community dwellers
To investigate the prevalence and severity of radiographically detected hallux valgus (HV) as well as associated risk factors among Japanese residents of Miyagawa, a mountain village located in the center of M...
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Article
The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group
We aimed to confirm the effect of combined treatment with celecoxib and rebamipide would be more effective than celecoxib alone for prevention of upper gastrointestinal (GI) events.
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Article
The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone
Breast cancer has the potential to metastasize to bone, causing debilitating symptoms. Although many tumor cells have thrombin-generating systems originating from tissue factor (TF), therapy in terms of the co...
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Article
Open AccessSoluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors
Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a f...
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Article
Open AccessProtective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb
Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage to skeletal muscle. The purposes of this study were 1) to assess the histological findings of ...
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Article
Open AccessEffect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study
Platelet-rich plasma (PRP) is a fraction of plasma in which several growth factors are concentrated at high levels. The active soluble releasate isolated following platelet activation of PRP (PRP-releasate) ha...
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Article
Prevalence and characteristics of unilateral knee osteoarthritis in a community sample of elderly Japanese: do fractures around the knee affect the pathogenesis of unilateral knee osteoarthritis?
The purpose of this study was to investigate the prevalence and characteristics of unilateral knee osteoarthritis (KOA), to investigate what percent of contralateral healthy knees in patients with unilateral K...
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Article
Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux
We evaluated hemostatic markers in patients who underwent major orthopedic surgery, including total hip and total knee arthroplasty, and were treated for the prophylaxis of deep vein thrombosis (DVT) with or w...
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Article
Open AccessThe adverse effect of an unplanned surgical excision of foot soft tissue sarcoma
Malignant soft tissue tumors of the foot are extremely rare and thus can be prematurely excised without appropriate preoperative evaluation. The present study compares adverse effects between unplanned and pla...
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Article
Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement
The efficacy of measuring anti-Xa activity was evaluated in major orthopedic surgery patients receiving thrombo-prophylaxis with Fondaparinux. Although 98 orthopedic patients including those receiving total hi...
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Article
Risk factors for the incidence and progression of radiographic osteoarthritis of the knee among Japanese
This longitudinal study aimed to identify risk factors for the incidence and progression of radiographic knee osteoarthritis (OA). We examined the inhabitants of Miyagawa village aged ≥65 years every two years...
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Article
A novel hyperthermia treatment for bone metastases using magnetic materials
Patients with bone metastases in the extremities sometimes require surgical intervention to prevent deterioration of quality of life due to a pathological fracture. The use of localized radiotherapy combined w...
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Article
Distribution and role of tenascin-C in human osteoarthritic cartilage
Tenascin-C (TN-C) is expressed in the cartilage of osteoarthritis (OA). We examined whether TN-C was involved in cartilage repair of the diseased joints. Human articular cartilage samples were obtained from pa...
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Article
Retrospective clinical study of the efficacy of lower-dose methotrexate and infliximab therapy in patients with rheumatoid arthritis
The objective of this study is to compare the long-term outcomes of infliximab therapy with lower-dose methotrexate (MTX; ≤4 mg per week) and with standard-dose MTX (≥6 mg per week) in Japanese rheumatoid arth...
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Article
Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report
A rare case of post-radiation epithelioid hemangioendothelioma arising in a congenital hemangioma of the lower leg 18 years after radiotherapy is reported. At 7 years of age, the patient underwent partial rese...
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Article
Ganglion cyst arising from the posterolateral capsule of the knee
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Article
Clinical application of a handy intraoperative measurement device for lumbar segmental instability
We describe the development of a new device that permits handy intraoperative measurement of lumbar segmental instability. The subjects comprised 80 patients with lumbar degenerative disease. Relationships bet...