5 Result(s)

Article

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

PHF6 mutations (PHF6^MT) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in MN. Here we show three main findings in our comprehensive ...

Yasuo Kubota, **aorong Gu, Laila Terkawi, Juraj Bodo… in Nature Communications (2024)

Article

Author Correction: Molecular patterns identify distinct subclasses of myeloid neoplasia

Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari… in Nature Communications (2024)

Article

Molecular patterns identify distinct subclasses of myeloid neoplasia

Genomic mutations drive the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia. While morphological and clinical features have dominated the classical criteria for diagnosis and classificatio...

Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari… in Nature Communications (2023)

Article

Development and characterization of patient-derived xenografts from non-small cell lung cancer brain metastases

Non-small cell lung cancer (NSCLC) brain metastasis cell lines and in vivo models are not widely accessible. Herein we report on a direct-from patient-derived xenograft (PDX) model system of NSCLC brain metast...

Andrew M. Baschnagel, Saakshi Kaushik, Arda Durmaz, Steve Goldstein… in Scientific Reports (2021)

Article

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Despite high initial efficacy, targeted therapies eventually fail in advanced cancers, as tumors develop resistance and relapse. In contrast to the substantial body of research on the molecular mechanisms of r...

Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz… in Nature Communications (2020)