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Article
Anna Pasetto
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Open AccessAutologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR ...
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Open AccessMemory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
T cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients. Such T cells can be detected in tumor infiltrating lymphocytes, but whether such cells can be det...
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Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-indu...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Steven Rosenberg and colleagues report that PD-1 is a biomarker of CD8+ T cells in the blood that recognize mutated neoantigens in melanoma.
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Functional Attributes of Responding T Cells in HCV Infection: The Recent Advances in Engineering Functional Antiviral T Cells
Hepatitis C virus (HCV) is one of the major causes of hepatocellular carcinoma (HCC) around the world. HCV promotes characteristics of cancer stem cells and the infected cells are insensitive to apoptotic sign...
