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Open AccessUnderrepresentation of ethnic minorities in UK COVID-19 trials: comment on a recent systematic review and meta-analysis
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Open AccessReal-world effectiveness of steroids in severe COVID-19: a retrospective cohort study
Randomised controlled trials have shown that steroids reduce the risk of dying in patients with severe Coronavirus disease 2019 (COVID-19), whilst many real-world studies have failed to replicate this result. ...
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Open AccessProtective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with efficacy in humans. Here we dem...
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Correction: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Nature Communications 2: Article number: 601 (2011); Published: 20 December 2011; Updated: 19 September 2013. In the Methods section of this Article, the species of the tissue plasminogen activator secretory s...
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Open AccessThe utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malar...
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The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induc...
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Effective induction of high-titer antibodies by viral vector vaccines
A novel immunization strategy that involves prime-boost vaccination with a recombinant adenovirus-poxvirus vector can induce strong, antigen-specific antibody responses. Antibodies induced by this viral-vector...