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Open AccessGap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
In the cerebellum, granule cells make parallel fibre contact on (and excite) Golgi cells and Golgi cells inhibit granule cells, forming an open feedback loop. Parallel fibres excite Golgi cells synaptically, e...
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Article
Open AccessThe Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells
Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of reward...
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Article
Open AccessThe ability to maintain rhythm is predictive of ADHD diagnosis and profile
Attention deficit hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric disorder in the world. Currently, the diagnosis is based mainly on interviews, resulting in uncertainties in the clinical ...
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Open AccessEffects of working memory load and CS-US intervals on delay eyeblink conditioning
Eyeblink conditioning is used in many species to study motor learning and make inferences about cerebellar function. However, the discrepancies in performance between humans and other species combined with evi...
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Open AccessWeak correlations between cerebellar tests
Eyeblink conditioning, finger tap**, and prism adaptation are three tasks that have been linked to the cerebellum. Previous research suggests that these tasks recruit distinct but partially overlap** parts...
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Open AccessCharacterizing chromatin landscape from aggregate and single-cell genomic assays using flexible duration modeling
ATAC-seq has become a leading technology for probing the chromatin landscape of single and aggregated cells. Distilling functional regions from ATAC-seq presents diverse analysis challenges. Methods commonly u...
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Article
Open AccessAbsence of Parallel Fibre to Purkinje Cell LTD During Eyeblink Conditioning
Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanation for cerebellar motor learning such as classical eyeblink conditioning. Previous evidence against this inter...
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Open AccessLearning and Timing of Voluntary Blink Responses Match Eyeblink Conditioning
Can humans produce well-timed blink responses to a neutral stimulus voluntarily, without receiving any blink-eliciting, unconditional, stimulus? And if they can, to what degree does classical eyeblink conditio...
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Simple and Complex Spike Firing Patterns in Purkinje Cells During Classical Conditioning
Classical blink conditioning is known to depend critically on the cerebellum and the relevant circuitry is gradually being unravelled. Several lines of evidence support the theory that the conditioned stimulus...