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  1. No Access

    Article

    Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production

    Phospholipids, the most abundant membrane lipid components, are crucial in maintaining membrane structures and homeostasis for biofunctions. As a structurally diverse and tightly regulated system involved in m...

    Yi Liu, Quanli Liu, Anastasia Krivoruchko, Sakda Khoomrung… in Nature Chemical Biology (2020)

  2. No Access

    Article

    Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene

    Beta-elemene, a sesquiterpene and the major component of the medicinal herb Curcuma wenyu**, has antitumor activity against various types of cancer and could potentially serve as a potent antineoplastic drug. Ho...

    Yating Hu, Yong** J. Zhou, Jichen Bao… in Journal of Industrial Microbiology & Biote… (2017)

  3. No Access

    Article

    Expanding the product portfolio of fungal type I fatty acid synthases

    Integration of heterologous enzymes into the reaction chambers of fungal fatty acid synthases (FASs) demonstrates the capacity of these megaenzymes for engineered production of short- and medium-chain fatty ac...

    Zhiwei Zhu, Yong** J Zhou, Anastasia Krivoruchko… in Nature Chemical Biology (2017)

  4. No Access

    Article

    Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

    Recently, butanols (1-butanol, 2-butanol and iso-butanol) have generated attention as alternative gasoline additives. Butanols have several properties favorable in comparison to ethanol, and strong interest th...

    Anastasia Krivoruchko… in Journal of Industrial Microbiology & Biote… (2013)

  5. No Access

    Article

    Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans

    Red-eared slider turtles, Trachemys scripta elegans, can survive for several weeks without oxygen when submerged in cold water. We hypothesized that anaerobiosis is aided by adaptive up-regulation of the unfolded...

    Anastasia Krivoruchko, Kenneth B. Storey in Molecular and Cellular Biochemistry (2013)

  6. No Access

    Article

    Epigenetics in anoxia tolerance: a role for histone deacetylases

    The importance of epigenetics has been established in many key biological processes but the relevance of this regulatory mechanism to animal survival of low oxygen conditions has never been examined. To establ...

    Anastasia Krivoruchko, Kenneth B. Storey in Molecular and Cellular Biochemistry (2010)

  7. No Access

    Article

    Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans

    The effects of 20 h of anoxic submergence in cold water and 5 h of aerobic recovery on the heat shock response were analyzed in four organs of the anoxia-tolerant turtle Trachemys scripta elegans. Immunoblotting ...

    Anastasia Krivoruchko, Kenneth B. Storey in Journal of Comparative Physiology B (2010)