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Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1
The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases, and recent clinical trial data has shown benefit in ...
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Article
Open AccessML290 is a biased allosteric agonist at the relaxin receptor RXFP1
Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Her...