10 Result(s)
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Article
Alessandra Ciucci
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Open AccessDual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
High grade serous ovarian cancer (HGSOC) is highly lethal, partly due to chemotherapy resistance and limited availability of targeted approaches. Cyclin dependent kinases 12 and 13 (CDK12/13) are promising the...
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Open AccessPreclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application
Despite many improvements in ovarian cancer diagnosis and treatment, until now, conventional chemotherapy and new biological drugs have not been shown to cure the disease, and the overall prognosis remains poo...
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Open AccessIdentification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients
High-grade serous ovarian cancer (HGSOC) has poor survival rates due to a combination of diagnosis at advanced stage and disease recurrence as a result of chemotherapy resistance. In BRCA1 (Breast Cancer gene ...
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Open AccessIn search for biomarkers and potential drug targets for uterine serous endometrial cancer
Serous endometrial cancer (USC) is a challenging malignancy associated with metastasis, recurrence and poor outcome. To identify clinically relevant prognostic biomarkers, we focused on a panel of proteins sel...
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Open AccessKLF7: a new candidate biomarker and therapeutic target for high-grade serous ovarian cancer
In spite of great progress in the surgical and clinical management, until now no significant improvement in overall survival of High-Grade Serous Ovarian Cancer (HGSOC) patients has been achieved. Important as...
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Open AccessA combined ANXA2-NDRG1-STAT1 gene signature predicts response to chemoradiotherapy in cervical cancer
A better understanding of locally advanced cervical cancer (LACC) is mandatory for further improving the rates of disease control, since a significant proportion of patients still fail to respond or undergo re...
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In Situ Collection of Refractory Dust in the Upper Stratosphere: The DUSTER Facility
DUSTER (Dust from the Upper Stratosphere Tracking Experiment and Retrieval) is an instrument designed to collect nanometer to micrometer scale solid aerosol particles in the upper stratosphere on board balloon...
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Expression and characterization of biologically active human fas ligand produced in CHO cells
We describe an expression system for high-yield production of recombinant soluble human FasL (rsh-FasL) in CHO cells. After one round of selection for gene amplification, cell lines producing rsh-FasL up to 60...
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Tissue-specific expression of theHLA-DRA gene in transgenic mice
Transgenic mice were produced containing a 33 kilobase (kb) DNA fragment encompassing the five exons and all the known regulatory regions of the class IIHLA-DRA gene. The transgene displayed regulated expression ...
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Methylation state of the human HLA-DRa gene in transgenic mice
We describe the tissue-specific expression and the reconstitution of the canonical methylation state of the human HLA-DRa gene in transgenic mice.
