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Open AccessPolymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
There is clinical and scientific interest in develo** local anesthetics with prolonged durations of effect from single injections. The need for such is highlighted by the current opioid epidemic. Site 1 sodi...
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Article
Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing
The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of b...