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  1. Article

    Open Access

    Dynamics in treatment response and disease progression of metastatic colorectal cancer (mCRC) patients with focus on BRAF status and primary tumor location: analysis of untreated RAS-wild-type mCRC patients receiving FOLFOXIRI either with or without panitumumab in the VOLFI trial (AIO KRK0109)

    In mCRC, disease dynamics may play a critical role in the understanding of long-term outcome. We evaluated depth of response (DpR), time to DpR, and post-DpR survival as relevant endpoints.

    A. Kurreck, M. Geissler, U. M. Martens… in Journal of Cancer Research and Clinical On… (2020)

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  2. Article

    Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

    Diabetes frequently develops in patients with pancreatic disorders. We aimed to determine the lower threshold of beta cell area for diabetes manifestation as well as the impact of insulin sensitivity on glucos...

    J. J. Meier, T. G. K. Breuer, R. C. Bonadonna, A. Tannapfel, W. Uhl… in Diabetologia (2012)

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  3. No Access

    Article

    Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: 7-year follow-up of a rare clinicopathologic syndrome

    Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare clinical pathological syndrome. There have been only 49 cases of DIPNECH reported in the literature so far. We report a case of ...

    R. F. Falkenstern-Ge, M. Kimmich, G. Friedel… in Journal of Cancer Research and Clinical On… (2011)

  4. Article

    The non-invasive 13C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis

    Mitochondrial dysfunction plays a central role in the general pathogenesis of non-alcoholic fatty liver disease (NAFLD), increasing the risk of develo** steatosis and subsequent hepatocellular inflammation. ...

    M Banasch, M Ellrichmann, A Tannapfel, WE Schmidt… in European Journal of Medical Research (2011)

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  5. Article

    Erratum: The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways

    Correction to: Oncogene (2008) 27, 4557–4568; doi:10.1038/onc.2008.90; published online 14 April 2008 Since the publication of the above paper, the authors found inadvertent errors and mislabelings in Figures ...

    M Hassan, A Alaoui, O Feyen, A Mirmohammadsadegh, F Essmann, A Tannapfel… in Oncogene (2011)

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  6. Article

    TME quality in rectal cancer surgery

    The concept of total mesorectal excision has revolutionised rectal cancer surgery. TME reduces the rate of local recurrence and tumour associated mortality. However, in clinical trials only 50% of the removed ...

    T Herzog, O Belyaev, AM Chromik, D Weyhe… in European Journal of Medical Research (2010)

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  7. Article

    Determinants of glucose control in patients with chronic pancreatitis

    Diabetes frequently develops in patients with chronic pancreatitis (CP). Partial pancreatectomy has emerged as a treatment option for such patients. We addressed whether the development of diabetes in CP patie...

    H. Schrader, B. A. Menge, C. Zeidler, P. R. Ritter, A. Tannapfel, W. Uhl… in Diabetologia (2010)

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  8. No Access

    Article

    Antitumor activity of the HER2 dimerization inhibitor pertuzumab on human colon cancer cells in vitro and in vivo

    The monoclonal antibody pertuzumab represents the first HER2 dimerization inhibitor with unknown activity in colon cancer treatment. We examined the antitumor activity of pertuzumab as a single agent or in com...

    Michael Pohl, I. Stricker, A. Schoeneck… in Journal of Cancer Research and Clinical On… (2009)

  9. No Access

    Article

    Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group

    Microsatellite instability (MSI) is a potential indicator of prognosis in patients with colorectal cancer (CRC). To date, there are a limited number of studies which investigated its role in advanced CRC. Our ...

    C. I. Müller, K. Schulmann… in International Journal of Colorectal Disease (2008)

  10. No Access

    Article

    The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways

    The molecular causes for resistance of melanoma to apoptosis are currently only partly understood. In the present study, we examined gene transfer and expression of the proapoptotic BH3-only protein Noxa as an...

    M Hassan, A Alaoui, O Feyen, A Mirmohammadsadegh, F Essmann, A Tannapfel… in Oncogene (2008)

  11. No Access

    Article

    Basement membrane component laminin-5 is a target of the tumor suppressor Smad4

    The tumor suppressor Smad4 is involved in carcinogenesis mainly of the pancreas and colon. Functional inactivation of Smad4 is a genetically late event that occurs upon transition from premalignant stages to i...

    M Zapatka, D Zboralski, Y Radacz, M Böckmann, C Arnold, A Schöneck, S Hoppe… in Oncogene (2007)

  12. No Access

    Article

    Evaluation of potential mechanisms underlying genotype–phenotype correlations in multiple endocrine neoplasia type 2

    Distinct dominant activating mutations in the RET proto-oncogene are responsible for the development of multiple endocrine neoplasia type 2 (MEN 2). Concise examination of the mutated codons led to the detection ...

    N Miše, M Drosten, T Racek, A Tannapfel, B M Pützer in Oncogene (2006)

  13. No Access

    Article

    Does tumor heterogeneity limit the use of the Weiss criteria in the evaluation of adrenocortical tumors?

    Adrenal incidentalomas are detected more frequently with high-resolution imaging modalities. It is difficult to distinguish between benign and malignant lesions despite the so-called histologic Weiss criteria,...

    C. Pohlink, A. Tannapfel, U. Eichfeld… in Journal of Endocrinological Investigation (2004)