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Article
Open AccessErroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder
In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that the brain creates hierarchical sensory models via a bidirectio...
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Biotic environment reinforcing the pertinacious clinically relevant COVID-19 associated mucormycosis: First report from Kashmir valley, India
Immuno-compromised COVID-19 patients being treated with glucocorticoids like Dexamethasone for prolonged periods had led to the surge of mucormycosis. Mucor spores proliferate and spread faster in COVID afflicted...
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A dynamic subpopulation of CRISPR–Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage
Many CRISPR–Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein) systems, which provide bacteria with adaptive immunity against phages, are transcriptionally repressed ...
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Open AccessA safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications
Approved vaccines are effective against severe COVID-19, but broader immunity is needed against new variants and transmission. Therefore, we developed genome-modified live-attenuated vaccines (LAV) by recoding...
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Open AccessIncreased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...
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Mass spectrometry-based proteomic landscape of rice reveals a post-transcriptional regulatory role of N6-methyladenosine
Rice is one of the most important staple food and model species in plant biology, yet its quantitative proteomes are largely uncharacterized. Here we quantify the relative protein levels of over 15,000 genes a...
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Open AccessThiolated chitosan nanoparticles encapsulated nisin and selenium: antimicrobial/antibiofilm/anti-attachment/immunomodulatory multi-functional agent
The increase in the resistance of bacterial strains to antibiotics has led to research into the bactericidal potential of non-antibiotic compounds. This study aimed to evaluate in vitro antibacterial/ antibiof...
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Open AccessThe nature of the last universal common ancestor and its impact on the early Earth system
The nature of the last universal common ancestor (LUCA), its age and its impact on the Earth system have been the subject of vigorous debate across diverse disciplines, often based on disparate data and method...
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Obesity-induced inflammation: connecting the periphery to the brain
Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire body. This sustained inflammatory state disrupts the coordinated communication between the periphery and the brain,...
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The choice of path to resilience is crucial to the future of production forests
Resilience in production forests can be achieved through natural ecological processes or repeated intensive interventions. We caution that ‘coerced’ resilience derived from intense and repeated human inputs ma...
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Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME...
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The potential application of Czenspinskia transversostriata in biological control
Phytoseiid predatory mites are one of the most important groups of biocontrol agents, commonly used in biological control. The ability to produce these predatory mites economically, at high density on cheap fa...
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The neural network RTNet exhibits the signatures of human perceptual decision-making
Convolutional neural networks show promise as models of biological vision. However, their decision behaviour, including the facts that they are deterministic and use equal numbers of computations for easy and ...
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Open AccessIdentification and characterization of specific motifs in effector proteins of plant parasites using MOnSTER
Plant pathogens cause billions of dollars of crop loss every year and are a major threat to global food security. Identifying and characterizing pathogens effectors is crucial towards their improved control. B...
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Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection
Arthropod-borne pathogens are responsible for hundreds of millions of infections in humans each year. The blacklegged tick, Ixodes scapularis, is the predominant arthropod vector in the United States and is respo...
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Open AccessTemplate-independent enzymatic synthesis of RNA oligonucleotides
RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver on anticipated future demand. Here, we report the development...
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Vitamin C Alleviates Neurobehavioral Deficits, IGF1 Expression, and Neuronal Damage Induced by Chronic Social Isolation Stress in the Hippocampus of Adult Male Rats
Social isolation stress (SIS) is associated with emotional and cognitive deficits. Here, we examined the impact of prolonged treatment with vitamin C on memory work and anxiety-like actions in chronic SIS rats...
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Robust immunity conferred by combining COVID-19 vaccine platforms in older adults
SARS-CoV-2 infections are typically more severe with increased age. Vaccination can reduce morbidity and mortality, but the age-associated decline in immune function could limit vaccine efficacy in older adult...
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Traditional Herbal Remedies Used in the Management of Urolithiasis by the Tribals of Purulia District, West Bengal, India
The tribal populations in Purulia district directly or indirectly rely on medicinal plants for their basic medical needs. Urolithiasis is the production of stones (calculi) in the kidney, bladder, or urethra, ...
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Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of diverse organic solutes across the plasma membrane is well studied, their necessary ongoin...
