32 Result(s)
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Open AccessA case–control study in Shanghai of fruit and vegetable intake and endometrial cancer
In a population-based case–control study of 832 incident endometrial cancer cases and 846 frequency-matched controls among Chinese women in Shanghai, using a validated food-frequency questionnaire, dietary hab...
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Open AccessExpression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma
Clinically, human glioblastoma (GBM) may develop de novo or from a low-grade glioma (secondary GBM), and molecular alterations in the two pathways may differ. This study examined the status of Survivin expression...
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Open AccessDetection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT–PCR detection of cytokeratin 19 mRNA
The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 an...
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Open AccessFrequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer
The role of secreted frizzled-related protein (SFRP) genes in gastric cancer remains largely unknown. We determined the frequency and functional significance of SFRPs hypermethylation in human gastric cancer. The...
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Open AccessEnhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells
Overexpression of Aurora-A kinase has been correlated with cancer susceptibility and poor prognosis in several human cancers. In this study, we evaluated the effect of inhibition of Aurora-A kinase on cell cyc...
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Open AccessHedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy
The zinc finger protein glioma-associated oncogene homologue 1 (Gli-1) is a critical component of the Hedgehog (Hh) signalling pathway, which is essential for morphogenesis and stem-cell renewal, and is dysreg...
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Open AccessDLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers
Promoter CpG methylation of tumour suppressor genes (TSGs) is an epigenetic biomarker for TSG identification and molecular diagnosis. We screened genome wide for novel methylated genes through methylation subt...
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Open AccessComparison and combination of blood-based inflammatory markers with faecal occult blood tests for non-invasive colorectal cancer screening
Faecal occult blood tests (FOBTs) are widely used for colorectal cancer (CRC) screening. Blood-based inflammatory markers have been suggested as alternative or supplementary non-invasive CRC screening tests.
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Open AccessOverexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma
The cyclin-dependent kinase inhibitor 3 (CDKN3) has been perceived as a tumour suppressor. Paradoxically, CDKN3 is often overexpressed in human cancer. It was unclear if CDKN3 overexpression is linked to alternat...
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Open AccessProspective changes in global DNA methylation and cancer incidence and mortality
Methylation of repetitive elements Alu and LINE-1 in humans is considered a surrogate for global DNA methylation. Previous studies of blood-measured Alu/LINE-1 and cancer risk are inconsistent.
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Open AccessPhase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment
This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced bil...
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Open AccessSGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway
Although inhibition of SGK1 has been shown to delay cancer progression, the underlying mechanisms have not yet been elucidated.
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Article
Open AccessHaplotype analysis suggest that the MLH1 c.2059C > T mutation is a Swedish founder mutation
Lynch syndrome (LS) predisposes to a spectrum of cancers and increases the lifetime risk of develo** colorectal- or endometrial cancer to over 50%. Lynch syndrome is dominantly inherited and is caused by def...
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Open AccessGenome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome
We conducted a genome-wide scan to identify non-synonymous SNPs (nsSNPs) that might influence survival after a diagnosis of colorectal cancer (CRC).
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Open AccessSOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
Sex-determining region Y-box (SRY-box) containing gene 9 (SOX9) expression confers cancer stem cell features. However, SOX9 function in intrahepatic cholangiocarcinoma (iCCA) is unknown. This study investigate...
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Open AccessComplementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
Most patients with KIT-mutant gastrointestinal stromal tumours (GISTs) benefit from imatinib, but treatment resistance results from outgrowth of heterogeneous subclones with KIT secondary mutations. Once resis...
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Correction: Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
The additional information of this manuscript originally stated that the authors declare no competing interests. This statement was incorrect, and should instead have stated the following:
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Open AccessTumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages
The progression and metastasis of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the tumour microenvironment. Most tumour-associated macrophages (TAMs) are M2 phenotype macrophages, which norma...
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Open AccessDKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer
Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported.
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Open AccessNine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection
Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patie...
