21 Result(s)
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Article
Open AccessTumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumou...
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Open AccessNCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway
Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function...
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miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
Previous reports have confirmed that miR-206 participates in inflammatory cardiomyopathy, but its definite mechanism remains elusive. This study aims to elucidate the potential mechanism of miR-206 in septic c...
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Retraction Note: MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice
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Article
Open AccessMYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1
Diffuse large B-cell lymphoma (DLBCL) is the leading cause of mortality from invasive hematological malignancies worldwide. MicroRNA-7-5p (miR-7-5p) has been shown to be a tumor suppressor in several types of ...
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Correction: miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
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Open AccessMechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
Morphogenesis and cell state transitions must be coordinated in time and space to produce a functional tissue. An excellent paradigm to understand the coupling of these processes is mammalian hair follicle dev...
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Open AccessTCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling
Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinfo...
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Open AccessPreeclampsia-associated lncRNA FEZF1-AS1 regulates cell proliferation and apoptosis in placental trophoblast cells through the ELAVL1/NOC2L axis
LncRNAs have been shown to be involved in and control the biological processes of multiple diseases, including preeclampsia (PE). The impairment of trophoblast cell proliferation is recognized as a significant...
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Article
Open Access(−)-Guaiol triggers immunogenic cell death and inhibits tumor growth in non-small cell lung cancer
(−)-Guaiol is a sesquiterpenoid found in many traditional Chinese medicines with potent antitumor activity. However, its therapeutic effect and mechanism in non-small cell lung cancer (NSCLC) have not been ful...
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Open AccessDevelopment and validation of a two glycolysis-related LncRNAs prognostic signature for glioma and in vitro analyses
Mounting evidence suggests that there is a complex regulatory relationship between long non-coding RNAs (lncRNAs) and the glycolytic process during glioma development. This study aimed to investigate the progn...
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Article
Open AccessMiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma
The primary purpose was to unveil how the miR-146b-5p/SEMA3G axis works in clear cell renal cell carcinoma (ccRCC).
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Article
Correction to: TAK1 is involved in sodium L‑lactate‑stimulated p38 signaling and promotes apoptosis
A correction to this paper has been published: https://doi.org/10.1007/s11010-021-04184-4
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Article
Open AccessChromosomal aberration arises during somatic reprogramming to pluripotent stem cells
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has opened new therapeutic possibilities. However, karyotypic abnormalities detected in iPSCs compromised their utility, especially chromos...
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Author Correction: piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessRole and mechanism of the Th17/Treg cell balance in the development and progression of insulin resistance
The pathogenic mechanism of insulin resistance and associated diseases such as metabolic syndrome and diabetes remains unclear. Since inflammatory cytokines secreted by T cells play an important role in immune...
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Author Correction: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells
In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1–14 instead of 46–59. These errors have now been corrected in all online v...
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Open AccessThe expression and functional role of a FOXC1 related mRNA-lncRNA pair in oral squamous cell carcinoma
The Fork head box C1 (FOXC1) gene is overexpressed in multiple malignant tumors and is functionally correlated with tumor progression. However, its’ role in oral squamous cell carcinoma (OSCC) is still unclear...
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Article
Open AccessRNA interference mediated pten knock-down inhibit the formation of polycystic ovary
Pten (phosphatase and tensin homolog deleted on chromosome 10), a kind of tumor suppressor gene, plays important roles in female reproductive system. But its expression and roles in the f...
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Article
Open AccessThree isoforms of the Atg16L1 protein contribute different autophagic properties
The mammalian Atg16L1 protein consists of a coiled-coil domain and a tryptophan-aspartic acid (WD) repeat domain and is involved in the process of autophagy. However, the mechanisms underlying the effect of th...
