5,267 Result(s)
within
Article
**u Tao
Biomedicine
-
Article
Breakdown of articular cartilage proteoglycans by lymphokine-activated macrophages
Lymphokine supernatants (LE) prepared from antigen sensitive lymphocytes caused an inhibition of migration of macrophages from capillary tubes. Control supernatants (LC) had no effect. The lymphokine supernatants...
-
Article
The influence of membrane mutations on metastasis
-
Article
Kmeriol and Other Aromatic Constituents of Kmeria Duperreana
The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytot...
-
Article
Molecular genetics of PKU in Eastern Europe: A nonsense mutation associated with haplotype 4 of the phenylalanine hydroxylase gene
Phenylketonuria (PKU) is a genetic disorder secondary to a deficiency of hepatic phenyalanine hydroxylase (PAH). Several mutations in thePAH gene have recently been reported, and linkage disequilibrium was observ...
-
Article
Detection of β-thalassemia mutations in the Chinese using amplified DNA from dried blood specimens
This paper describes DNA polymerase chain reaction (PCR) amplification directly from dried blood specimens for the detection of the β-thalassemia mutation in China. Target DNA was amplified to span the β-globi...
-
Article
Structure Elucidation and Thermospray High-Performance Liquid Chromatography/Mass Spectroscopy (HPLC/MS) of the Microbial and Mammalian Metabolites of the Antimalarial Arteether
Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized to six new metabolites in addition to those previously reported (3). Large-scale fermentations with Cun...
-
Article
Sesquiterpene Lactones and Other Constituents from a Cytotoxic Extract of Michelia floribunda
The pentane and CHC13 fractions of a crude extract of Michelia floribunda exhibited cytotoxic activity when tested in KB and P388 tumor cell cultures. Repeated chromatography led to the isolation of three cytotox...
-
Article
PAH 399 GTA(Val)→GTT(Val), a new silent mutation found in the Chinese
A silent mutation or sequence polymorphism, an A to T substitution at codon 399 in exon 11 of the phenylalanine hydroxylase (PAH) gene has been identified by DNA sequence analysis in the Chinese. The frequenci...
-
Article
α2-Adrenoceptor modulation of rat ventral hippocampal 5-hydroxytryptamine release in vivo
The putative existence of a functional α2-adrenoceptor-mediated modulation of 5-HT release in vivo from serotonergic neuronal terminals in the ventral hippocampus was investigated using intracerebral microdialysi...
-
Article
Identification of Hantaan virus-related structures in kidneys of cadavers with haemorrhagic fever with renal syndrome
The etiologic agent of haemorrhagic fever with renal syndrome (HFRS), Hantaan virus, was first isolated in 1976. Since then numerous Hantaan-like viruses have been isolated and five serotypes of Hantavirus hav...
-
Article
Disposition of epirubicin in an oily contrast medium after intravenous and intrahepato-arterial administration in liver cancer: a preliminary report
The present study reports findings on the disposition of epirubicin after an intrahepato-arterial administration of the Lipiodol-drug complex, prepared by mixing the drug-aqueous phase with the iodized oil by ...
-
Article
Expression of beta-2-microglobulin by nasopharyngeal carcinoma
Serum beta-2-microglobulin (beta 2M) levels of 274 Chinese patients with different stages of nasopharyngeal carcinoma at presentation and that of 35 patients who developed distant metastases post-treatment wer...
-
Article
Molecular Cloning of Two cDNAs Encoding the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferases (mUGT Br/p)
-
Article
Molecular Cloning of the Alcohol/Hydroxysteroid Form (mST a1) of Sulfotransferase from Mouse Liver
-
Article
Decomposition of Arteether in Simulated Stomach Acid Yielding Compounds Retaining Antimalarial Activity
In simulated stomach acid (aqueous 0.01 M HC1, 37°C) β-arteether decomposed (half-life, 441 ± 17 min) to dihydroartemisinin, which subsequently rearranged to a new compound (1) having an endoperoxide group and an...
-
Article
The interaction of the mu-opioid receptor and G protein is altered after chronic morphine treatment in rats
The interaction of µ-opioid receptors and G proteins after chronic morphine treatment was investigated in rats. Male Sprague-Dawley rats (200–260 g) were rendered tolerant to morphine by i.p. injections of inc...
-
Article
The correlation of cardiac mass with arterial haemodynamics of resistive and capacitive load in rats with normotension and established hypertension
In hypertensive animals and humans, cardiac hypertrophy may occur as a consequence of an external load on the heart. Several studies have suggested that the non-pulsatile components of arterial haemodynamics, ...
-
Article
HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
A crucial requirement in the rational design of a prophylactic vaccine against the hu-uman immunodeficiency virus (HIV) is to establish whether or not protective immunity can occur following natural infection....
-
Article
Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis
B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89–101. The disease is associated with the major histocom...
-
Article
Mice lacking ornithine–δ–amino–transferase have paradoxical neonatal hypoornithinaemia and retinal degeneration
Deficiency of ornithine–δ–aminotransferase (OAT) in humans causes hyperornithinaemia and gyrate atrophy (GA), a blinding chorioretinal degeneration. Surprisingly, OAT–deficient mice produced by gene targeting ...
