Summary
The etiologic agent of haemorrhagic fever with renal syndrome (HFRS), Hantaan virus, was first isolated in 1976. Since then numerous Hantaan-like viruses have been isolated and five serotypes of Hantavirus have been recognized. Serological studies indicate that these viruses are globally distributed, with each serotype occurring in specific areas. Hantaan virus has been intensively studied antigenically, biochemically, and genetically. However there is still a paucity of information on the pathogenesis of Hantaan virus in the human host.
In this paper, we report the detection by thin section immune electron microscopy of the occurrence of numerous dense precipitates, typical inclusion bodies, a surface antigen layer, as well as Hantaan virion-like structures in the kidneys of patients that died during the acute phase of HFRS. These findings may shed some light on understanding the pathogenesis of HFRS in target organs most affected by the disease, such as the kidneys.
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References
Lee HW (1988) Global update on distribution of haemorrhagic fever with renal syndrome and Hantaviruses. Virus Inform Exchange Newslett 5: 82–84
Lee HW, van der Groen G (1989) Haemorrhagic fever with renal syndrome. Prog Med Virol 36: 62–102
Lee HW, Lee PW (1976) Korean haemorrhagic fever. I. Demonstration of causative antigen and antibodies. Kor J Intern Med 19: 371–383
Lee HW, Lee PW, Johnson KM (1978) Isolation of the etiologic agent of Korean haemorrhagic fever. J Infect Dis 137: 298–308
Hung Tao (1985) Morphology and morphogenesis of viruses of haemorrhagic fever with renal syndrome (HFRS). I. Some peculiar aspects of the morphogenesis of various strains of HFRS virus. Intervirology 23: 97–108
Hung Tao (1987) Morphology and morphogenesis of viruses of haemorrhagic fever with renal syndrome (HFRS). II. Inclusion bodies — ultrastructural markers of Hantavirus infected cells. Intervirology 27: 45–52
Hung Tao (1988) Atlas of haemorrhagic fever with renal syndrome. Science Press, Bei**g
Hung Tao (1983) Morphological evidence for identifying the viruses of haemorrhagic fever with renal syndrome as candidate members of theBunyaviridae family. Arch Virol 78: 137–144
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Tao, H., **g-Yi, Z., Yun-Ming, T. et al. Identification of Hantaan virus-related structures in kidneys of cadavers with haemorrhagic fever with renal syndrome. Archives of Virology 122, 187–199 (1992). https://doi.org/10.1007/BF01321127
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DOI: https://doi.org/10.1007/BF01321127