891 Result(s)
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Article
A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin
We report the identification of a full-length novel β-spectrin II gene (βSpIIΣ2) in human brain. The βSpIIΣ2 gene has 32 exons encoding an actin-binding domain, followed by 17-spectrin repeats, and a short COO...
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Article
Efficient and Accurate Time-Step** Schemes for Integrate-and-Fire Neuronal Networks
To avoid the numerical errors associated with resetting the potential following a spike in simulations of integrate-and-fire neuronal networks, Hansel et al. and Shelley independently developed a modified time...
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Article
Defective NF-κB activation in virus-infected neuronal cells is restored by genetic complementation
The interferon-beta (IFNβ) gene is not inducible in neuronal cells in response to measles virus (MV) due to lack of nuclear factor kappa B (NF-κB) activation. NF-κB is normally sequestered in the cytoplasm by an ...
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Article
Pharmacological study of the novel compound FLZ against experimental parkinson’s models and its active mechanism
FLZ is a synthetic new derivative of squamosamide. Pharmacological study found that FLZ given orally improved the abnormal behavior caused by the functional disturbance of dopaminergic and cholinergic neurons ...
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Article
bHLH genes and retinal cell fate specification
The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body ...
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Article
Determining natural arm configuration along a reaching trajectory
Owing to the flexibility and redundancy of neuromuscular and skeletal systems, humans can trace the same hand trajectory in space with various arm configurations. However, the joint trajectories of typical unr...
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Article
Developmental change of α-gustducin expression in the mouse fungiform papilla
Developmental changes in the distribution pattern of taste buds in newborn mouse have not been previously elucidated, and little work has been done to examine the postnatal alteration of the expression of α-gu...
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Article
Increased protein and mRNA expression of endostatin in the ischemic brain tissue of rabbits after middle cerebral artery occlusion
To explore the changes of endostatin (a strong anti-angiogenesis factor) and vascular endothelial growth factor (VEGF) in the brain tissues of rabbits following cerebral ischemia induced by middle cerebral art...
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Article
Frames of reference during implicit and explicit learning
There is a significant overlap between the processes and neural substrates of spatial cognition and those subserving memory and learning. However, for procedural learning, which often is spatial in nature, we ...
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Article
Impaired predictive motor timing in patients with cerebellar disorders
The ability to precisely time events is essential for both perception and action. There is evidence that the cerebellum is important for the neural representation of time in a variety of behaviors including ti...
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Article
Expression changes of microtubule associated protein 1B in the brain of Fmr1 knockout mice
To explore the regulatory effect of fragile X mental retardation protein (FMRP) on the translation of microtubule associated protein 1B (MAP1B).
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Article
Triptolide Upregulates NGF Synthesis in Rat Astrocyte Cultures
Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by d-amphetamine and prevent the loss of dopaminer...
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Article
ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells
ADAM23, belonging to ADAM (A Disintegrin And Metalloprotease) protein family, is mainly expressed in brain. P19 cells could differentiate into neuroectodermal cell lineage after cell aggregates have been induc...
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Article
Roles of NF-κB in central nervous system damage and repair
NF-κB family is a kind of nuclear factors in B lymphocyte that can bind to the immunoglobulin κ-chain enhancer and enhance transcriptional activity. NF-κB/Rel proteins, as a dimeric transcription factor, contr...
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Article
Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats
Status epilepticus (SE) is associated with a significant risk of cognitive impairment, and the increase of nitric oxide (NO) releasing has been reported during SE. We investigated the effects of neuronal nitri...
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Article
The selective 5-HT1A receptor antagonist WAY-100635 inhibits neuronal activity of the ventromedial prefrontal cortex in a rodent model of Parkinson’s disease
The ventral part of the medial prefrontal cortex (mPFC) plays an important role in initiation and control of voluntary movement, mood and cognition. However, after the degeneration of the nigrostriatal pathway...
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Article
In vitro Methionine5-Enkephalin Degradation Kinetics by Human Brain Preparations
Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid a...
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Article
Rapid Decrease of GAD 67 Content Before the Convulsion Induced by Hyperbaric Oxygen Exposure
Exposure to hyperbaric oxygen (HBO) can lead to seizures, the etiology of which is not completely understood. Glutamic acid decarboxylase (GAD) plays a very important role in maintaining excitatory-inhibitory ...
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Article
Open AccessPioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
Previous studies have suggested that peroxisome proliferator activated receptor-gamma (PPAR-γ)-mediated neuroprotection involves inhibition of microglial activation and decreased expression and activity of ind...
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Article
Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord
To investigate changes of 5-hydroxytryptamine (5-HT) and its synthesis rate-limiting enzyme tryptophan hydroxylase (TPH) in the ventral horn of spinal cord after exercise-induced fatigue, and to further discus...
