1,847 Result(s)

Article

Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas

The clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale, population-based study aimed to comprehensively outline these traits and construct ...

Tao Chang, Rui Zhang, Jiahao Gan, Yuan Yang, Yanhui Liu, Yan Ju, **aodong Niu… in BMC Cancer (2024)

Article

Author Correction: LINE-1 transcription activates long-range gene expression

**ufeng Li, Luyao Bie, Yang Wang, Yaqiang Hong, Ziqiang Zhou, Yiming Fan… in Nature Genetics (2024)

Article

METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer

Diabetic foot ulcer (DFU) is the most devastating complication of diabetes mellitus (DM) and plays a major role in disability and death in DM patients. NADH: ubiquinone oxidoreductase subunit B5 (NDUFB5) plays...

Tao Wang, Xu Li, Yue Tao, **aojun Wang, Limeng Li… in Journal of Translational Medicine (2024)

Article

Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial

Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This...

Jianjun Qin, Liyan Xue, Anlin Hao, **aofeng Guo, Tao Jiang, Yunfeng Ni… in Nature Medicine (2024)

Article

Notoginsenoside R1 promotes Lgr5⁺ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...

Zhi-lun Yu, Rui-yang Gao, Cheng Lv, **ao-long Geng… in Acta Pharmacologica Sinica (2024)

Article

Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8⁺ T and NK cells

Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...

Jia-zheng Jiao, Yang Zhang, Wen-juan Zhang, Min-di He… in Acta Pharmacologica Sinica (2024)

Article

TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription

The development of distinct dendritic cell (DC) subsets, namely, plasmacytoid DCs (pDCs) and conventional DC subsets (cDC1s and cDC2s), is controlled by specific transcription factors. IRF8 is essential for th...

**angyi Shen, **aoguang Li, Tao Wu, Tingting Guo… in Cellular & Molecular Immunology (2024)

Article

Screening of potential hub genes involved in Kidney Wilms tumor via bioinformatics analysis and experimental validation

Wilms tumor (WT) is the most common pediatric embryonal tumor. Improving patient outcomes requires advances in understanding and targeting the multiple genes and cellular control pathways, but its pathogenesis...

Qiang Zeng, Tingting Liu, Lilu Qin, Chen Wang, Guangbei Peng, Zhong Liu… in BMC Cancer (2024)

Article

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2^V617F-induced myeloproliferative neoplasms

Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, **bing Zhu, Ailin Zhao… in Blood Cancer Journal (2024)

Article

Intestinal mRNA expression profiles associated with mucosal healing in ustekinumab-treated Crohn's disease patients: bioinformatics analysis and prospective cohort validation

Variations exist in the response of patients with Crohn’s disease (CD) to ustekinumab (UST) treatment, but the underlying cause remains unknown. Our objective was to investigate the involvement of immune cells...

Qing Li, Zicheng Huang, Hongsheng Yang, Jian Tang… in Journal of Translational Medicine (2024)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

Correlation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis

The role of hemoglobin (HGB) in common malignant tumors remains unclear.

Guo-Sheng Li, Tao Huang, **g-**ao Li, Jun Liu, **ang Gao, Nuo Yang… in BMC Cancer (2024)

Article

TACE combined Lenvatinib plus Camrelizumab versus TACE alone in efficacy and safety for unresectable hepatocellular carcinoma: a propensity score-matching study

To compare the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined Lenvatinib plus Camrelizumab (TLC) in unresectable hepatocellular carcinoma (uHCC) with those of TACE alone .

Zhihong Tang, Tao Bai, Tao Wei, **aobo Wang, Jie Chen, Jiazhou Ye, Shangqi Li… in BMC Cancer (2024)

Article

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Methods for the targeted integration of genes in mammalian genomes suffer from low programmability, low efficiencies or low specificities. Here we show that phage-assisted continuous evolution enhances prime-e...

Smriti Pandey, **n D. Gao, Nicholas A. Krasnow… in Nature Biomedical Engineering (2024)

Article

Integrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer

Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.

Siyu Zhou, Baian Tao, Yujie Guo, Jichun Gu… in Journal of Translational Medicine (2024)