25 Result(s)

Article

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

**ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

Article

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

IP3R2-mediated Ca²⁺ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca²⁺) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer

Lung cancer is the leading cause of cancer-related mortality worldwide. CNOT3, a subunit of the CCR4-NOT complex, has recently been suggested to be overexpressed in lung cancer and involved in tumor malignancy...

Lin **g, Meng-En Zhai, Mei-Rui Qian, Yi-Ming Li, Ming-Wei Han… in Cell Death Discovery (2023)

Article

Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression

Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain family member 9 (CARD9) acts as a...

Yan Liu, Yi-hui Shao, Jun-meng Zhang, Ying Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin

Lung cancer has the highest mortality rate in the world, and mounting evidence suggests that cancer stem cells (CSCs) are associated with poor prognosis, recurrence, and metastasis of lung cancer. It is urgent...

Chia-Hao Tung, Jia-En Wu, Meng-Fan Huang, Wen-Lung Wang… in Cancer Cell International (2023)

Article

MALAT1/ mir-1-3p mediated BRF2 expression promotes HCC progression via inhibiting the LKB1/AMPK signaling pathway

The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to play a vital role in the occurrence and development of various tumors. However, the underlying mecha...

Guang-Zhen Li, Guang-**ao Meng, Guo-Qiang Pan, **ao Zhang… in Cancer Cell International (2023)

Article

Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1

Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is...

Zi-Yi Zhou, Tian-Fang Chang, Zhi-Bin Lin, Yu-Tong **g, Li-Shi Wen… in Cell Death & Disease (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products

Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleoti...

Wei Li, Wang-Sheng Jiang, Ya-Ru Su, Ke-Wu Tu, Lin Zou… in Cell Death & Disease (2023)

Article

Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to rec...

Huijie Bian, Liang Chen, Zhao-Hui Zheng… in Signal Transduction and Targeted Therapy (2023)

Article

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vect...

Zhi-Guo Lu, Jie Shen, Jun Yang, **g-Wen Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response

Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response. The inhibition and reprogramming of the immune system play critical...

Dong-Rui Wang, **an-Lin Wu, Ying-Li Sun in Signal Transduction and Targeted Therapy (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, ...

**ao-Ning Zhang, Kai-Di Yang, Cong Chen, Zhi-Cheng He, Qiang-Hu Wang… in Cell Research (2021)

Article

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (...

Jia-yuan Zhang, Bo Zhou, Ru-yue Sun, Yuan-li Ai, Kang Cheng, Fu-nan Li… in Cell Research (2021)

Article

Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling

Vagus nerve stimulation (VNS) restores autonomic balance, suppresses inflammation action and minimizes cardiomyocyte injury. However, little knowledge is known about the VNS’ role in cardiomyocyte phenotype, s...

Bin Luo, Yan Wu, Shu-lin Liu, **ng-yuan Li, Hong-rui Zhu, Lei Zhang… in Cell Death & Disease (2020)

Article

RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent manner

Runt-Related Transcription Factor 1 (RUNX1) is highly expressed in the Mesenchymal (Mes) subtype of glioblastoma (GBM). However, the specific molecular mechanism of RUNX1 in Mes GBM remains largely elusive. In...

Kai Zhao, **aoteng Cui, Qixue Wang, Chuan Fang, Yanli Tan… in Cell Death & Disease (2019)