8 Result(s)

Article

Preclinical evaluation of the SARS-CoV-2 M^pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir

Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still needed, particularly for individuals in whom vaccines are less effective, such as the immunocompromised, to preven...

**aoxin Chen, **aodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou… in Nature Microbiology (2024)

Article

Clinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8

The pathogenicity and virulence of the Omicron strain have weakened significantly pathogenesis of Omicron variants. Accumulating data indicated accessory proteins play crucial roles in host immune evasion and ...

Zhizhong Tang, Pei Yu, Qianfang Guo, Mingxiao Chen, Yu Lei, Lei Zhou… in Virology Journal (2023)

Article

Prevalence and predisposing factors of depressive symptoms in continuous ambulatory peritoneal dialysis patients: a cross-sectional single center study

The aim of this study was to identify the prevalence of the depressive symptoms and the factors associated with the depressive symptoms in peritoneal dialysis patients.

Yu Chen, Peng Li, Lei Zhang, Yanfei Zhang, Luyi **e, Jianying Niu in BMC Nephrology (2023)

Article

Correction: Heparanase promotes endothelial-to-mesenchymal transition in diabetic glomerular endothelial cells through mediating ERK signaling

Kaili Chang, Qiyuan **e, Jianying Niu, Yong Gu, Zhonghua Zhao… in Cell Death Discovery (2022)

Article

Heparanase promotes endothelial-to-mesenchymal transition in diabetic glomerular endothelial cells through mediating ERK signaling

Glomerular endothelial cells (GEnCs) dysfunction occurs at the early stage of diabetic nephropathy (DN). One of its characteristics is endothelial-to-mesenchymal transition (EndMT). Heparanase (HPSE) is the on...

Kaili Chang, Qiyuan **e, Jianying Niu, Yong Gu, Zhonghua Zhao… in Cell Death Discovery (2022)

Article

Transient neonatal antibiotic exposure increases susceptibility to late-onset sepsis driven by microbiota-dependent suppression of type 3 innate lymphoid cells

Extended early antibiotic exposure in the neonatal intensive care unit is associated with an increased risk for the development of late-onset sepsis (LOS). However, few studies have examined the mechanisms inv...

**nying Niu, Sarah Daniel, Dharmendra Kumar, Elizabeth Y. Ding… in Scientific Reports (2020)

Article

Decreased Ang-(1–7) and Downregulated Intrarenal RAS May Contribute to the Direct Podocyte Injury With Proteinuria in Preeclampsia

The mechanisms of proteinuria development in preeclampsia (PE) are still enigmatic. Renin-angiotensin system (RAS) components may play a role. Maternal serum and urinary concentrations of angiotensin-(1-7) [An...

Guixiang Chen PhD, **aohong ** MM, Lihong Zhang MM… in Reproductive Sciences (2019)

Article

Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway

Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparan...

Qiao**g Qin, Jianying Niu, Zhaoxia Wang, Wangjie Xu… in Cardiovascular Diabetology (2013)