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  1. No Access

    Article

    The Singapore National Precision Medicine Strategy

    Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic–phenotypic databases...

    Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes… in Nature Genetics (2023)

  2. No Access

    Article

    A multi-omics integrative network map of maize

    Networks are powerful tools to uncover functional roles of genes in phenotypic variation at a system-wide scale. Here, we constructed a maize network map that contains the genomic, transcriptomic, translatomic...

    Linqian Han, Wanshun Zhong, Jia Qian, Minliang **, Peng Tian… in Nature Genetics (2023)

  3. No Access

    Article

    RNA m6A regulates transcription via DNA demethylation and chromatin accessibility

    Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing and maintaining cell identity. The interplay between differ...

    Shuang Deng, Jialiang Zhang, Jiachun Su, Zhixiang Zuo, Lingxing Zeng… in Nature Genetics (2022)

  4. No Access

    Article

    Discovery of common and rare genetic risk variants for colorectal cancer

    To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consor...

    Jeroen R. Huyghe, Stephanie A. Bien, Tabitha A. Harrison, Hyun Min Kang… in Nature Genetics (2019)

  5. No Access

    Article

    Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease

    A meta-analysis of exome-wide association studies for blood lipid levels in East Asian populations identifies a novel coding variant. Exome array data from the Global Lipids Genetics Consortium were integrated...

    **angfeng Lu, Gina M Peloso, Dajiang J Liu, Ying Wu, He Zhang, Wei Zhou… in Nature Genetics (2017)

  6. No Access

    Article

    Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

    John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of Europe...

    Norihiro Kato, Marie Loh, Fumihiko Takeuchi, Niek Verweij, Xu Wang… in Nature Genetics (2015)

  7. No Access

    Article

    Identification of six new susceptibility loci for invasive epithelial ovarian cancer

    Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 know...

    Karoline B Kuchenbaecker, Susan J Ramus, Jonathan Tyrer, Andrew Lee… in Nature Genetics (2015)

  8. Article

    Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

    Nat. Genet. 42, 759–763 (2010); published online 22 August 2010; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors now find no evidence to support...

    Li-Dong Wang, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, **n Song, Yan **… in Nature Genetics (2014)

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  9. No Access

    Article

    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

    Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and a...

    Chen Wu, Zhaoming Wang, **n Song, **ao-Shan Feng, Christian C Abnet… in Nature Genetics (2014)

  10. No Access

    Article

    A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

    Ding Ma, **ng **e, Yongyong Shi and colleagues report a genome-wide association study of cervical cancer in the Han Chinese population. They identify two new susceptibility lociat 4q12 and 17q12.

    Yongyong Shi, Li Li, Zhibin Hu, Shuang Li, Shixuan Wang, Jihong Liu… in Nature Genetics (2013)

  11. No Access

    Article

    Large-scale genoty** identifies 41 new loci associated with breast cancer risk

    Douglas Easton, Per Hall and colleagues report meta-analyses of genome-wide association studies for breast cancer, including 10,052 cases and 12,575 controls, followed by genoty** using the iCOGS array in an...

    Kyriaki Michailidou, Per Hall, Anna Gonzalez-Neira, Maya Ghoussaini… in Nature Genetics (2013)

  12. No Access

    Article

    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

    Paul Pharoah, Joellen Schildkraut, Thomas Sellers and colleagues report a meta-analysis of genome-wide association studies for epithelial ovarian cancer and genoty** using the iCOGS array in 18,174 cases and...

    Paul D P Pharoah, Ya-Yu Tsai, Susan J Ramus, Catherine M Phelan… in Nature Genetics (2013)

  13. No Access

    Article

    Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

    Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

    Li-Dong Wang, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, **n Song, Yan **… in Nature Genetics (2010)

  14. No Access

    Article

    Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC

    Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors id...

    Cheng Quan, Yun-Qing Ren, Lei-Hong **ang, Liang-Dan Sun, Ai-E Xu… in Nature Genetics (2010)

  15. No Access

    Article

    Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource

    Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region. Knowledge of the genome of this parasite should improve understanding of schistosome-host interactions, biomedical ...

    Wei Hu, Qing Yan, Da-Kang Shen, Feng Liu, Zhi-Dong Zhu, Huai-Dong Song… in Nature Genetics (2003)