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Article
Detection of clinically significant prostate cancer following initial omission of biopsy in multiparametric MRI era
Multiparametric prostate MRI (mpMRI) is being increasingly adopted for work-up of prostate cancer. For patients selected to omit biopsy, we identified factors associated with repeat MRI, eventual prostate biop...
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Article
A method for noninvasive electrical stimulation of the diaphragm
Stimulated contraction of the diaphragm by non-invasive electrical stimulation of the phrenic nerve is demonstrated. A specialized device including a programmable current source and an electrode system has bee...
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Article
Open AccessDiet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer
Transition from traditional high-fiber to Western diets in urbanizing communities of Sub-Saharan Africa is associated with increased risk of non-communicable diseases (NCD), exemplified by colorectal cancer (C...
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Article
Microstructure, Mechanical, and Corrosion Properties of Mg-Zn-Ga Alloy after Hot Rolling
The effect of hot rolling on the structure and mechanical properties of the Mg-2Zn-2Ga (wt.%) alloy has been studied. The original cast alloy plates after heat treatment were subjected to rolling from an initi...
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Article
A device for non-invasive electrical stimulation of the phrenic nerve
Results obtained from studies of the development of a device for non-invasive electrical stimulation of the phrenic nerve are presented. A block diagram of the device and schematics of key functional blocks ar...
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Article
Mechanical and Corrosion Properties of Hot-Extruded Mg–Zn–Ga Alloys
The effect of hot extrusion on the mechanical and corrosion properties of Mg–Zn–Ga alloys intended for medicine purposes is studied. The Mg4Zn4Ga alloy is shown to exhibit a favorable level of mechanical prope...
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Article
Optimizing detection of clinically significant prostate cancer through nomograms incorporating mri, clinical features, and advanced serum biomarkers in biopsy naïve men
To develop nomograms that predict the detection of clinically significant prostate cancer (csPCa, defined as ≥GG2 [Grade Group 2]) at diagnostic biopsy based on multiparametric prostate MRI (mpMRI), serum biom...
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Article
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Comprehensive enhancer discovery is challenging because most enhancers, especially those contributing to complex diseases, have weak effects on gene expression. Our gene regulatory network modeling identified ...
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Article
Open AccessSevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms
Perioperative risk factors, including the choice of anesthetics, may influence ovarian cancer recurrence after surgery. Inhalational anesthetic sevoflurane and intravenous agent propofol might affect cancer ce...
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Article
Real-world use of MRI for risk stratification prior to prostate biopsy
The utilization of MRI to risk stratify elevated PSA prior to prostate biopsy has been inconsistently adopted and varies considerably by practice setting. This study aims to evaluate the usage and performance ...
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Article
A Device for Transcutaneous Stimulation of the Diaphragm
Results obtained during the development of an original device for noninvasive transcutaneous stimulation of the diaphragm using electromagnetic radiation in the terahertz frequency range are presented. The blo...
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Article
Open AccessRectal swabs as a viable alternative to faecal sampling for the analysis of gut microbiota functionality and composition
Faecal or biopsy samples are frequently used to analyse the gut microbiota, but issues remain with the provision and collection of such samples. Rectal swabs are widely-utilised in clinical practice and previo...
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Article
A transcriptomic model for homologous recombination deficiency in prostate cancer
Tumors with mutations associated with homologous recombination deficiency (HRD) are uncommon in prostate cancer (PCa) and variably responsive to PARP inhibition. To better identify tumors with HRD, we develope...
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Article
Author Correction: Immune regulation by fungal strain diversity in inflammatory bowel disease
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Article
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction
The pancreas and liver arise from a common pool of progenitors. However, the underlying mechanisms that drive their lineage diversification from the foregut endoderm are not fully understood. To tackle this qu...
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Article
A community approach to the cancer-variant-interpretation bottleneck
As guidelines, therapies and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public-domain, crowd-sourced and adaptable knowledgeba...
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Article
Open AccessPublisher Correction: OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health
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Article
Open AccessOCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health
Inherited retinal disorders and dry age-related macular degeneration are characterized by the degeneration and death of different types of photoreceptors at different rate and locations. Advancement of new the...
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Article
Immune regulation by fungal strain diversity in inflammatory bowel disease
The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation1–6. Although ab...
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Article
Metal ion chelation enhances tissue plasminogen activator (tPA)-induced thrombolysis: an in vitro and in vivo study
Stroke is the third leading cause of death in the United States and the leading cause of adult disability. Despite enormous research efforts including many clinical trials, tissue plasminogen activator (tPA) r...
