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  1. Article

    Open Access

    Efficacy of acupuncture as an adjunctive treatment to patients with stable COPD: a multicenter, randomized, sham-controlled trial protocol

    Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and the third leading cause of death worldwide. Previous evidence has shown that acupuncture may be an effective complementary alter...

    Liuyang Huang, Sha Yang, Guixing Xu, Qin Luo in BMC Complementary Medicine and Therapies (2024)

  2. Article

    Open Access

    The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway

    Immunosuppressive cells play important roles in generating an immunosuppressive tumor microenvironment and facilitating tumor immune escape. However, the molecular mechanisms underlying their immunosuppressive...

    **ongzhi Lin, Shuhan Yang, Caichuan Zhou, Chengcheng Ao, Dongsheng Sun in Medical Oncology (2023)

  3. No Access

    Article

    Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

    Previous studies have revealed that patients with hypertrophic cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating potential HCM subtypes among these patients. Here, 793 pati...

    Jiaqi Dai, Tao Wang, Ke Xu, Yang Sun, Zongzhe Li, Peng Chen in Frontiers of Medicine (2023)

  4. Article

    Open Access

    Manual acupuncture as prophylaxis for migraine without aura: study protocol for a multi-center, randomized, single-blinded trial

    Migraine is a highly prevalent neurological disorder. It is the third most prevalent disorder and the seventh highest cause of disability worldwide. Acupuncture may be a viable prophylactic treatment option fo...

    Jiao Chen, Siyuan Zhou, Mingsheng Sun, Yanan Wang, **aoqin Chen, Taipin Guo in Trials (2022)

  5. Article

    Open Access

    Fine Comparison of the Efficacy and Safety Between GB242 and Infliximab in Patients with Rheumatoid Arthritis: A Phase III Study

    This phase III trial (NCT04178850) evaluated the efficacy, safety, and immunogenicity of GB242, an infliximab biosimilar, vs. infliximab (Remicade®) reference product in patients with moderate-to-severe active rh...

    Yanying Liu, Shengyun Liu, Lin Liu, **aowei Gong, Ju Liu in Rheumatology and Therapy (2022)

  6. Article

    Impact of COVID-19 pandemic on outpatient appointments of rheumatic patients in a non-outbreak area of China

    Coronavirus disease 2019 (COVID-19) infection has caused huge impacts on all of people’s lives and health systems. In response to the COVID-19 pandemic, China was the first country to impose lockdown. We aimed...

    Tianhua **e MD, Dong Wang MD, **a Wang MD in Wiener klinische Wochenschrift (2021)

  7. No Access

    Article

    Lack of association between TNF polymorphism and ankylosing spondylitis susceptibility in HLA-B27-positive population: a meta-analysis

    Human leukocyte antigen (HLA)-B27 plays a crucial role in the pathogenesis of AS. TNF polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have be...

    Naiwen Hu, Dongxia Liu, Na Zhao, **a Wang, Yanyan Bai in European Spine Journal (2021)

  8. No Access

    Article

    The association of polymorphisms in TNF and ankylosing spondylitis in common population: a meta-analysis

    Studies investigating the association between the polymorphisms in TNF and ankylosing spondylitis have been reported the conflicting results. Here we performed a meta-analysis based on the evidence available f...

    Naiwen Hu, ** Chen, Shanjuan Wang, Gangying Yuan, Qinqin Wang in European Spine Journal (2021)

  9. Article

    Open Access

    Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder

    Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome data to prioritize recessive inherited genes (RIGs) with biallelically ...

    Lin Wang, Yi Zhang, Kuokuo Li, Zheng Wang, **aomeng Wang, Bin Li in Molecular Autism (2020)

  10. Article

    Open Access

    Genetic evidence of gender difference in autism spectrum disorder supports the female-protective effect

    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a male-to-female prevalence of 4:1. However, the genetic mechanisms underlying this gender difference remain unclear. Mutation burde...

    Yi Zhang, Na Li, Chao Li, Ze Zhang, Hua**g Teng, Yan Wang in Translational Psychiatry (2020)

  11. No Access

    Article

    A comparative study of the genetic components of three subcategories of autism spectrum disorder

    The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) controversially combined previously distinct subcategories of autism spectrum disorder (ASD) into a single diagnostic cate...

    **chen Li, Shanshan Hu, Kun Zhang, Leisheng Shi, Yi Zhang in Molecular Psychiatry (2019)

  12. No Access

    Article

    Safety and Efficacy of Selective Neurectomy of the Gastrocnemius Muscle for Calf Reduction in 300 Cases

    Liposuction alone is not always sufficient to correct the shape of the lower leg, and muscle reduction may be necessary.

    Haibin Wang, **ang Xu, Zhongsheng Sun, Shengkang Luo in Aesthetic Plastic Surgery (2015)

  13. Article

    Open Access

    Retraction Note To: Functional activation of Proline-rich Tyrosine Kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

    Meiying Wang, Hongsheng Sun, Wei Zhang, Yuanchao Zhang in BMC Musculoskeletal Disorders (2015)

  14. Article

    Open Access

    Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma

    Non-mucinous bronchioloalveolar carcinoma (BAC) is considered the early stage of lung adenocarcinoma and is classified as the lung adenocarcioma in situ (AIS) by the International Association for the Study of ...

    Zhenfa Zhang, Anlei Wang, Bingsheng Sun, Zhongli Zhan in Journal of Cardiothoracic Surgery (2013)

  15. Article

    Open Access

    Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity

    Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. Previous studies have suggested that interferon-lambda 1 (IFN-λ1), a type III interferon, plays an immunomodulatory...

    Qian Wu, Qingrui Yang, Elaine Lourenco, Hongsheng Sun in Arthritis Research & Therapy (2011)

  16. Article

    Open Access

    Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease characterized by activated T cells and polyclonally activated B cells that produce autoantibodies. Activation of autoreactive ...

    Meiying Wang, Hongsheng Sun, Wei Zhang, Yuanchao Zhang in BMC Musculoskeletal Disorders (2009)