247 Result(s)
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Biomedicine
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Astrocytes-Secreted WNT5B Disrupts the Blood–Brain Barrier Via ROR1/JNK/c-JUN Cascade During Meningitic Escherichia Coli Infection
The blood–brain barrier (BBB) is a complex structure that separates the central nervous system (CNS) from the peripheral blood circulation. Effective communication between different cell types within the BBB i...
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Open AccessDUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma
Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI re...
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Characteristics of T cell premature senescence in maintenance hemodialysis patients
Uremia-associated immunodeficiency, mainly characterized by T cell dysfunction, exists in patients on maintenance hemodialysis (MHD) and promotes systemic inflammation. However, T cell senescence, one of the c...
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The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review
Regulatory T cells (Tregs) play vital roles in controlling immune reactions and maintaining immune tolerance in the body. The targeted destruction of epidermal melanocytes by activated CD8+T cells is a key event ...
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Open AccessDirect transposition of native DNA for sensitive multimodal single-molecule sequencing
Concurrent readout of sequence and base modifications from long unamplified DNA templates by Pacific Biosciences of California (PacBio) single-molecule sequencing requires large amounts of input material. Here...
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The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice
Doxorubicin (DOX) is one of the most frequently used chemotherapeutic drugs belonging to the class of anthracyclines. However, the cardiotoxic effects of anthracyclines limit their clinical use. Recent studies...
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Brain white matter microstructural alterations in patients with systemic lupus erythematosus: an automated fiber quantification study
This study aimed to identify damaged segments of brain white matter fiber tracts in patients with systemic lupus erythematosus (SLE) using diffusion tensor imaging (DTI)-based automated fiber quantification (A...
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DDLA: a double deep latent autoencoder for diabetic retinopathy diagnose based on continuous glucose sensors
The current diagnosis of diabetic retinopathy is based on fundus images and clinical experience. However, considering the ineffectiveness and non-portability of medical devices, we aimed to develop a diagnosti...
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Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice
Hypothermia is an essential environmental factor in gastrointestinal diseases, but the main molecular mechanisms of pathogenesis remain unclear. The current study sought to better understand how chronic cold s...
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Time-varying EEG networks of major depressive disorder during facial emotion tasks
Depression is a mental disease involved in emotional and cognitive impairments. Neuroimaging studies have found abnormalities in the structure and functional network of brain for major depressive disorder (MDD...
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TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I
Innate immune response is the first line of defense for the host against virus invasion. One important response is the synthesis and secretion of type I interferon (IFN-I) in the virus-infected host cells. Her...
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Open AccessFascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord
Mechanical softening of the glial scar region regulates axonal regeneration to impede neurological recovery in central nervous system (CNS) injury. Microglia, a crucial cellular component of the glial scar, fa...
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Open AccessCDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its effects on stemness and metastasis.
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Dynamic functional connectivity correlates of mental workload
Tasks with high mental workload often involve higher cognitive functions of the human brain and complex information flow involving multiple brain regions. However, the dynamics of functional connectivity betwe...
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Similarities and differences of dynamic and static spontaneous brain activity between left and right temporal lobe epilepsy
To comprehensively investigate the potential temporal dynamic and static abnormalities of spontaneous brain activity (SBA) in left temporal lobe epilepsy (LTLE) and right temporal lobe epilepsy (RTLE) and to d...
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Open AccessLow-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP–RIPK1–NF-κB axis and influencing autophagy
Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even...
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Open AccessHypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1
Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlap** ...
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Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
The proteasome is a crucial mechanism that regulates protein fate and eliminates misfolded proteins, playing a significant role in cellular processes. In the context of lung cancer, the proteasome’s regulatory...
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Open Access3D-printed PCL framework assembling ECM-inspired multi-layer mineralized GO-Col-HAp microscaffold for in situ mandibular bone regeneration
In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for bone tissue engineering. However, the challenge of creating scaffolds that mimic n...
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Open AccessAdvances in AI and machine learning for predictive medicine
The field of omics, driven by advances in high-throughput sequencing, faces a data explosion. This abundance of data offers unprecedented opportunities for predictive modeling in precision medicine, but also p...
