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Open AccessNear-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes
Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell label...
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Open Access3D vasculature segmentation using localized hybrid level-set method
Intensity inhomogeneity occurs in many medical images, especially in vessel images. Overcoming the difficulty due to image inhomogeneity is crucial for the segmentation of vessel image.
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Addendum: Editorial Expression of Concern: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
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Retraction Note: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
Nat. Biotechnol. 34, 768–773 (2016); published online 2 May 2016; addendum published after print 28 November 2016; retracted 26 July 2017; 10.1038/nbt.3547 We are retracting our study because of the continued ...
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Open AccessTemporal and spatial characteristics of sediment sources on the southern Yangtze Shoal over the Holocene
The sediment sources of the Yangtze Shoal were traced by analysing surface and core sediment particle size, detrital and clay minerals, carbon and nitrogen isotopes, and radioisotope dating. In the estuary, th...
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Open AccessEvaluating the effect and mechanism of upper limb motor function recovery induced by immersive virtual-reality-based rehabilitation for subacute stroke subjects: study protocol for a randomized controlled trial
There is compelling evidence of beneficial effects of non-immersive virtual reality (VR)-based intervention in the rehabilitation of patients with stroke, whereby patients experience both the real world and th...
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Open AccessDenitrification characterization of dissolved oxygen microprofiles in lake surface sediment through analyzing abundance, expression, community composition and enzymatic activities of denitrifier functional genes
The responses of denitrifiers and denitrification ability to dissolved oxygen (DO) concent in different layers of surface lake sediments are still poorly understood. Here, the optimal denitrification condition...
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Open AccessTrehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement
Random-pattern skin flaps are commonly used and valuable tools in reconstructive surgery, however, post-operative random skin flap necrosis remains a major and common complication. Previous studies have sugges...
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Open AccessFGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
Random-pattern skin flap is commonly used for surgical tissue reconstruction due to its ease and lack of axial vascular limitation. However, ischemic necrosis is a common complication, especially in distal par...
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Article
Open AccessTime series classification based on statistical features
This paper presents a statistical feature approach in fully convolutional time series classification (TSC), which is aimed at improving the accuracy and efficiency of TSC. This method is based on fully convolu...
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Open AccessLRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential for inducing the neuromuscular junction (NMJ) formation in muscle fibers, and LRP4 plays a critical role in dendritic development and ...
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Open AccessSTING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear. Previous research demonstrated that the cyclic GMP-A...
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Open AccessAssociations of sleep characteristics with atopic disease: a cross-sectional study among Chinese adolescents
Adolescence, as a transition between childhood and adulthood, is a critical stage for the long-term control of atopic diseases. We aim to determine if sleep characteristics are involved in the increased risk o...
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Open AccessDegradation pathway of triazole fungicides and synchronous removal of transformation products via photo-electrocatalytic oxidation tandem MoS2 adsorption
A simple and effective tandem process of photo-electrocatalytic oxidation (PECO)-MoS2 adsorption was developed for the synchronous removal of triazole fungicides (TFs) and toxicological transformation products (T...
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Open AccessCauses of death and effect of non-cancer-specific death on rates of overall survival in adult classic Hodgkin lymphoma: a populated-based competing risk analysis
The improved prognosis of classic Hodgkin lymphoma (cHL) has been accompanied by elevated risks of non–cancer-specific death (non-CSD). The aim of this study was to verify the occurrence of non-CSD and its eff...
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Open AccessMassive pericardial effusion and pleural effusion: cardiac and pleural infiltration in newly diagnosed acute myeloid leukemia
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Open AccessTransmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum
Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of...
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Open AccessGBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling
Identifying the mechanism of glioma progression is critical for diagnosis and treatment. Although studies have shown that guanylate-binding protein 2(GBP2) has critical roles in various cancers, its function i...
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Open AccessMFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis
Intervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease accompanied by complex pathophysiological mechanisms. Increasing evidence indicates that NLRP3 inflammasome mediated pyropt...
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Open AccessLRP4 is required for the olfactory association task in the piriform cortex
Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, ...