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Article
Open AccessIdentification of subgroups and development of prognostic risk models along the glycolysis–cholesterol synthesis axis in lung adenocarcinoma
Lung cancer is one of the most dangerous malignant tumors affecting human health. Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Both glycolytic and cholesterogenic pathways play critica...
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Article
Open AccessAnalysis of global gene expression using RNA-sequencing reveals novel mechanism of Yanghe **chuan decoction in the treatment of asthma
Yanghe **chuan decoction (YPD) has been used for asthma treatment for many years in China. We sought to understand the mechanism of YPD, and find more potential targets for YPD-based treatment of asthma.
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Article
Open AccessOral microbiota disorder in GC patients revealed by 2b-RAD-M
Microbiota alterations are linked with gastric cancer (GC). However, the relationship between the oral microbiota (especially oral fungi) and GC is not known. In this study, we aimed to apply 2b-RAD sequencing...
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Article
Open AccessGenetic associations between circulating metabolic biomarkers and lung cancer in East Asians and Europeans
Metabolic biomarkers are reported to be associated with the risk of lung cancer (LC). However, the observed associations from epidemiological studies are either inconsistent or inconclusive.
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Article
Open AccessThe role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression
Recent years have witnessed a growing academic interest in the effects of lncRNAs on tumors. LINC01419 is found to facilitate proliferation and metastasis of lung adenocarcinoma (LUAD) cells, but there is a gr...
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Article
Open AccessARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
Cancer expression of PD-L1 suppresses anti-tumor immunity. PD-L1 has emerged as a remarkable therapeutic target. However, the regulation of PD-L1 degradation is not understood. Here, we identify several compou...
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Article
Open AccessCircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1
Lung adenocarcinoma (LUAD) has long been one of the predominant reasons for the global cancer-linked mortality. The tumor progression is shown by several studies to be promoted by increased glycolysis. Enolase...
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Article
Open AccessmTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase
mTOR signaling pathway is deregulated in most cancers and uncontrolled cell cycle progression is a hallmark of cancer cell. However, the precise molecular mechanisms of the regulation of DNA replication and ch...
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Article
Open AccessPhotoelectrochemical oxidation of organic substrates in organic media
There is a global effort to convert sunlight into fuels by photoelectrochemically splitting water to form hydrogen fuels, but the dioxygen byproduct bears little economic value. This raises the important quest...
