20 Result(s)

Article

Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Lymph node metastasis (LNM) facilitates distant tumor colonization and leads to the high mortality in patients with intrahepatic cholangiocarcinoma (ICC). However, it remains elusive how ICC cells subvert immu...

Bao-Ye Sun, Zhu-Tao Wang, Ke-Zhu Chen, Yang Song, **g-Fang Wu… in Cell Death Discovery (2024)

Article

Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...

Chunchun Yuan, **ang-Tian Yu, **g Wang, Bing Shu, **ao-Yun Wang… in Cell Discovery (2024)

Article

HMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis

Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...

**g-Yu Yang, **n-Yuan Lei, Kai-Yue He, **-Rong Guo, Meng-Jie Liu… in Cell Death & Disease (2024)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Retraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2022)

Article

DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis

Previously, we reported the expression of DLX4 isoforms (BP1 and DLX7) in myeloid leukemia, but the functional role of DLX4 isoforms remains poorly understood. In the work described herein, we further determined ...

**g-dong Zhou, Yang-**g Zhao, Jia-yan Leng, Yu Gu… in Cellular & Molecular Biology Letters (2022)

Article

Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence of variant strains with mutated S pro...

Miao-Miao Zhao, Yun Zhu, Li Zhang, Gongxun Zhong, Linhua Tai, Shuo Liu… in Cell Discovery (2022)

Article

Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance

Increased glycolysis is a hallmark of tumor, which can provide tumor cells with energy and building blocks to promote cell proliferation. Recent studies have shown that not only the expression of glycolytic ge...

Peng Liu, Si-Jia Sun, Ying-Jie Ai, Xu Feng, Yi-Min Zheng, Yun Gao… in Cell Death & Disease (2022)

Article

Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4

Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-...

Yu-Shui Ma, Ji-Bin Liu, Lan Lin, Hui Zhang, Jian-Jun Wu, Yi Shi… in Cell Death Discovery (2021)

Article

A novel somatosensory spatial navigation system outside the hippocampal formation

Spatially selective firing of place cells, grid cells, boundary vector/border cells and head direction cells constitutes the basic building blocks of a canonical spatial navigation system centered on the hippo...

**aoyang Long, Sheng-Jia Zhang in Cell Research (2021)

Article

Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), ha...

Qun Chen, Wu-Jun Wang, Yun-Xuan Jia, Hao Yuan, Peng-Fei Wu, Wan-Li Ge… in Cell & Bioscience (2021)

Article

Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis

Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix (ECM)-producing myofibroblasts, a phenotypes with multiple roles in hepatic fibrogenesis and carcinogenesis via crossta...

Gao Liu, Jian Sun, Zhang-Fu Yang, Cheng Zhou, Pei-Yun Zhou… in Cell Death & Disease (2021)

Article

Establishing a deeper understanding of the osteogenic differentiation of monolayer cultured human pluripotent stem cells using novel and detailed analyses

Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is a popular topic in bone tissue engineering. Although many improvements have been achieved, the low induction efficiency because ...

** Zhou, Jia-Min Shi, **g-E Song, Yu Han, Hong-Jiao Li… in Stem Cell Research & Therapy (2021)

Article

The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing

ZD55-IL-24 is similar but superior to the oncolytic adenovirus ONYX-015, yet the exact mechanism underlying the observed therapeutic effect is still not well understood. Here we sought to elucidate the underly...

Hai-Jun Hu, **u Liang, Hai-Lang Li, Chun-Ming Du, Jia-Li Hao… in Cell Death & Disease (2020)

Article

RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the ro...

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2020)

Article

Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review

Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding this devastating disease, PC still accounts for 3% o...

Jiang-Jiang Qin, **ang-Dong Cheng, Jia Zhang… in Cell Communication and Signaling (2019)

Article

Sphingosine 1 phosphate receptor-1 (S1P1) promotes tumor-associated regulatory T cell expansion: leading to poor survival in bladder cancer

Regulatory T cells (Tregs) represent an important contributor to cancer immune escape, but the molecular mechanism responsible for Treg expansion in tumors is heterogeneous and unclear. Here, we investigated t...

Yi-Na Liu, Han Zhang, Lin Zhang, Ting-Ting Cai, Dai-Jia Huang… in Cell Death & Disease (2019)

Article

BAP1 acts as a tumor suppressor in intrahepatic cholangiocarcinoma by modulating the ERK1/2 and JNK/c-Jun pathways

Current therapeutic options for intrahepatic cholangiocarcinoma (ICC) are very limited, which is largely attributed to poor understanding of molecular pathogenesis of ICC. Breast cancer type 1 susceptibility p...

Xu-**ao Chen, Yue Yin, Jian-Wen Cheng, Ao Huang, Bo Hu, **n Zhang… in Cell Death & Disease (2018)

Article

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death of nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic ...

Jian Chen, Jun-Jun **e, Meng-Yun **, Yun-Tao Gu, Cong-Cong Wu… in Cell Death & Disease (2018)

Article

Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma

Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression. However, its expression and role in intrahepati...

Nan **e, Jia-Bin Cai, Lu Zhang, Peng-Fei Zhang, Ying-Hao Shen… in Cell Death & Disease (2017)