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Role of altered prednisolone-specific lymphocyte sensitivity in chronic renal failure as a pharmacodynamic marker of acute allograft rejection after kidney transplantation
The effects of four immunosuppressive agents on the in vitro blastogenesis of peripheral blood lymphocytes activated by concanavalin A have been studied using cells from 26 healthy subjects, 34 patients with c...
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Article
The cardiac antiarrhythmic effects of polyunsaturated fatty acid
Each year in the United States alone some 250,000 persons die within one hour of an acute myocardial infarction. These deaths are largely due to ischemia-induced ventricular arrhythmias, primarily ventricular ...
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Polyunsaturated fatty acids exert antiarrhythmic actions as free acids rather than in phospholipids
Previous studies have shown that exogenous free n-3 polyunsaturated fatty acids (PUFA) can prevent tachyarrhythmias caused by specific agents in isolated cardiac myocytes. However, the question as to whether i...
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Prevention of ischemia-induced cardiac Sudden death by n−3 polyunsaturated fatty acids in dogs
The objective of this study was to obtain functional information associated with the prevention by n−3 polyunsaturated fatty acids (PUFA) of ischemia-induced fatal cardiac ventricular arrhythmias in the intact...
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n-3 fatty acids in the prevention of cardiac arrhythmias
In animals and probably in humans n-3 polyunsaturated fatty acids (PUFA) are antiarrhythmic. A report follows on the recent studies of the antiarrhythmic actions of PUFA. The PUFA stabilize the electrical acti...
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The Antiarrhythmic and Anticonvulsant Effects of Dietary N-3 Fatty Acids
It has been shown in animals and probably in humans, that n-3 polyunsaturated fatty acids (PUFAs) are antiarrhythmic. We report recent studies on the antiarrhythmic actions of PUFAs. The PUFAs stabilize the e...
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Article
Strengthening mechanisms in a rapidly solidified and aged Cu-Cr alloy
A single-roller melt spinning method was used to produce Cu-Cr microcrystal alloy ribbons. Upon proper aging treatment, the strength and hardness of the alloy were remarkably enhanced while the conductivity on...
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Article
Effect of air flow rate on scleroglucan synthesis by Sclerotium glucanicum in an airlift bioreactor with an internal loop
The effect of air flow rate upon scleroglucan production in batch cultures of S. glucanicum NRRL 3006 cultivated in airlift reactor with internal loop was studied using air flow rates from 0.25 m3/h to 1.00 m3/h...
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Article
Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells
The novel synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid (AHPN/CD437) has been proven to be a potent inducer of apoptosis in a variety of tumor cell types. However, the mec...
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Hydrodynamic characteristics and mixing behaviour of Sclerotium glucanicum culture fluids in an airlift reactor with an internal loop used for scleroglucan production
The filamentous fungus, Sclerotium glucanicum NRRL 3006, was cultivated in a 0.008 m3 airlift bioreactor with internal recirculation loop (ARL-IL) for production of the biopolymer, scleroglucan. The rheological b...
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Article
A new haplogroup pattern displayed in Fujian Han in China
Human Y-chromosomal binary polymorphisms have been considered to preserve the paternal genetic legacy and provide evidence on human evolution and the genetic relationships among and demographic history of dif...
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Article
Open AccessDecreased expression of the mannose 6- phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells
Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contrib...
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Effective transduction and stable transgene expression in human blood cells by a third-generation lentiviral vector
Difficulty in gene transduction of human blood cells, including hematopoietic stem cells, has hampered the development of gene therapy applications for hematological disorders, encouraging the development and ...
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Article
Fat-1 mice convert n-6 to n-3 fatty acids
Mammals cannot naturally produce omega-3 (n-3) fatty acids — beneficial nutrients found mainly in fish oil — from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply1. Here we sh...
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Open AccessDown-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes
The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is a multi-functional protein that has been implicated in regulation of cell growth and apoptosis. Cardiac myocytes express relatively...
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Abstracts of original contributions ASNC 2004 9th annual scientific session September 3-–October 3, 2004 New York, New York
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Open AccessA simplified method for analysis of polyunsaturated fatty acids
Analysis of fatty acid composition of biological materials is a common task in lipid research. Conventionally, preparation of samples for fatty acid analysis by gas chromatography involves two separate procedu...
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From Fat to Fat-1: A Tale of Omega-3 Fatty Acids
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Membrane Effects of the n-3 Fish Oil Fatty Acids, which Prevent Fatal Ventricular Arrhythmias
Fish oil fatty acids are known to exert beneficial effects on the heart and vascular systems. We have studied the membrane effects on ion channel conductance by the n-3 fish oil fatty acids that account for th...
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n-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland
In this study, we determined the phospholipid FA composition in the mammary gland of the transgenic Fat-1 mouse. This is the first animal model developed that can endogenously synthesize n−3 PUFA. The synthesi...