50 Result(s)

Article

Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion

The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identif...

Ya Fang, Jia-** Wan, Zheng Wang, Shi-Yang Song, Cao-Xu Zhang… in Nature Communications (2024)

Article

Future temperature-related hospitalizations from cardiovascular diseases among rural residents in southeastern China considering population aging

Future climate changes are projected to adversely affect mortality risk of cardiovascular disease (CVD) in urbanized regions. However, future temperature-related excess CVD hospitalizations in rural residents ...

Zhi-Ying Zhan, Jun Yang, Xue Zhong, **ao-Xu **e… in npj Climate and Atmospheric Science (2023)

Article

Feasibility and reproducibility of semi-automated longitudinal strain analysis: a comparative study with conventional manual strain analysis

Conventional approach to myocardial strain analysis relies on a software designed for the left ventricle (LV) which is complex and time-consuming and is not specific for right ventricular (RV) and left atrial ...

Gui-juan Peng, Shu-yu Luo, **ao-fang Zhong, **ao-xuan Lin… in Cardiovascular Ultrasound (2023)

Article

E-GWAS: an ensemble-like GWAS strategy that provides effective control over false positive rates without decreasing true positives

Genome-wide association studies (GWAS) are an effective way to explore genotype–phenotype associations in humans, animals, and plants. Various GWAS methods have been developed based on different genetic or sta...

Guang-Liang Zhou, Fang-Jun Xu, Jia-Kun Qiao, Zhao-Xuan Che… in Genetics Selection Evolution (2023)

Article

Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone

Cyclic di-GMP (c-di-GMP) transduces extracellular stimuli into intracellular responses, coordinating a plethora of important biological processes. Low levels of c-di-GMP are often associated with highly virule...

Shuyu Li, Hengxi Sun, Jianghan Li, Yujiao Zhao, Ruiying Wang… in Nature Communications (2022)

Article

Effects of long-term PM_2.5 exposure on metabolic syndrome among adults and elderly in Guangdong, China

We aimed to explore the association between long-term exposure to particulate matter ≤ 2.5 µm (PM_2.5) and metabolic syndrome (MetS) and its components including fasting blood glucose (FBG), blood pressure, trigly...

Xue-yan Zheng, Si-li Tang, Tao Liu, Ye Wang, **ao-jun Xu, Ni **ao… in Environmental Health (2022)

Article

Author Correction: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection

Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang… in Nature Communications (2022)

Article

Epidemiological and virological surveillance of influenza viruses in China during 2020–2021

During the coronavirus disease 2019 (COVID-19) pandemic, seasonal influenza activity declined globally and remained below previous seasonal levels, but intensified in China since 2021. Preventive measures to C...

Wei-juan Huang, Yan-hui Cheng, Min-ju Tan, Jia Liu… in Infectious Diseases of Poverty (2022)

Article

Comparison of CD146 +/− mesenchymal stem cells in improving premature ovarian failure

Mesenchymal stem cells (MSCs) are a heterogeneous group of subpopulations with differentially expressed surface markers. CD146 + MSCs correlate with high therapeutic and secretory potency. However, their thera...

Lin Zhang, Yang Sun, **ao-Xu Zhang, Yu-Bin Liu, Hui-Yan Sun… in Stem Cell Research & Therapy (2022)

Article

The genome of medicinal leech (Whitmania pigra) and comparative genomic study for exploration of bioactive ingredients

Leeches are classic annelids that have a huge diversity and are closely related to people, especially medicinal leeches. Medicinal leeches have been widely utilized in medicine based on the pharmacological act...

Lei Tong, Shao-**ng Dai, De-Jun Kong, Peng-Peng Yang, **n Tong… in BMC Genomics (2022)

Article

Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature

Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of varia...

Yuan-yuan Qi, **n-yu Zhao, **n-ran Liu, Yan-na Wang… in Arthritis Research & Therapy (2021)

Article

Photoinduced E to Z isomerization of tetraphenylethylene derivatives within organometallic supramolecular assemblies

Isolation of E-1,2-bis(4-bromophenyl)-1,2-diphenyl-ethylene from the E/Z isomer mixture obtained by a McMurry coupling reaction and reaction of this isomer with imidazole followed by N-alkylation with nBuBr and a...

**ao-Xu Liu, Yang Li, **n Li, F. Ekkehardt Hahn, Ying-Feng Han in Science China Chemistry (2021)

Article

A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection

SARS-CoV-2, the causative agent of COVID-19¹, features a receptor-binding domain (RBD) for binding to the host cell ACE2 protein^1–6. Neutralizing antibodies that block RBD-ACE2 interaction are candidates for the ...

Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang… in Nature Communications (2021)

Article

Incidence and risk factors of post-operative cognitive decline after ablation for atrial fibrillation

Catheter ablation is widely used in atrial fibrillation (AF) management. In this study, we are aimed to investigate the incidence of postprocedural cognitive decline in a larger population undergoing AF ablati...

**g Zhang, Shi-Jun **a, **n Du, Chao Jiang, Yi-Wei Lai… in BMC Cardiovascular Disorders (2021)

Article

LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity

Maintaining proper mitochondrial respiratory function is crucial for alleviating cardiac metabolic disorders during obesity, and mitophagy is critically involved in this process. Long non-coding RNA H19 (H19) ...

Shao-Hua Wang, **ao-Lin Zhu, Fei Wang, Si-Xu Chen, Zhi-Teng Chen… in Cell Death & Disease (2021)

Article

Physical activity, screen exposure and sleep among students during the pandemic of COVID-19

This study aimed to determine the levels of health-related behaviours (physical activity, screen exposure and sleep status) among Chinese students from primary, secondary and high schools during the pandemic o...

Yang-feng Guo, Min-qi Liao, Wei-li Cai, **ao-xuan Yu, Shu-na Li… in Scientific Reports (2021)

Article

Chidamide increases the sensitivity of refractory or relapsed acute myeloid leukemia cells to anthracyclines via regulation of the HDAC3 -AKT-P21-CDK2 signaling pathway

Induction therapy for acute myeloid leukemia (AML) is an anthracycline-based chemotherapy regimen. However, many patients experience a relapse or exhibit refractory disease (R/R). There is an urgent need for m...

Hao Wang, Yu-chen Liu, Cheng-ying Zhu… in Journal of Experimental & Clinical Cancer … (2020)

Article

microRNA-1271-5p/TIAM1 suppresses the progression of ovarian cancer through inactivating Notch signaling pathway

Ovarian cancer (OC) has been regarded as the most malignant gynecological neoplasm and often confers grave outcomes owing to the frequent metastasis and high recurrence. A previous study has demonstrated that ...

Feng-Juan Han, Jia Li, Ying Shen, Ying Guo, Yi-Chao Liu… in Journal of Ovarian Research (2020)

Article

ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection

Neospora caninum is an obligate intracellular protozoan that causes neosporosis, N. caninum infection is a major cause of abortion in cattle worldwide. Currently, specific treatment for neosporosis is not availab...

Lu Li, **ao-Cen Wang, Peng-Tao Gong, Nan Zhang, Xu Zhang, Shan Li… in Parasites & Vectors (2020)

Article

Efficacy and safety of YinQiSanHuang-antiviral decoction in chronic hepatitis B: study protocol for a randomized, placebo-controlled, double-blinded trial

Chronic hepatitis B (CHB) is a global public health problem. Antiviral therapy is the primary treatment. Studies have shown that a combined therapy of traditional Chinese medicine (TCM) and conventional antivi...

Qing-Juan Wu, Wen-Liang Lv, Juan-Mei Li, Ting-Ting Zhang, Wen-hui Zhou… in Trials (2020)