59 Result(s)

Article

Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain

Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However, it remains challenging to obtain the neural activity and th...

**ang Li, Yun Du, Jiang-Feng Huang, Wen-Wei Li, Wei Song… in Neuroscience Bulletin (2024)

Article

Neoantigen-augmented iPSC cancer vaccine combined with radiotherapy promotes antitumor immunity in poorly immunogenic cancers

Although irradiated induced-pluripotent stem cells (iPSCs) as a prophylactic cancer vaccine elicit an antitumor immune response, the therapeutic efficacy of iPSC-based cancer vaccines is not promising due to t...

Kevin Chih-Yang Huang, William Tzu-Liang Chen, Jia-Yi Chen, Chien-Yueh Lee… in npj Vaccines (2024)

Article

Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration

GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.

Chen-Yang Tao, **ao-Ling Wu, Shu-Shu Song, Zheng Tang, Yu-Fu Zhou… in Cellular Oncology (2024)

Article

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na⁺/K⁺-ATPase, has been implicated in the mouse model with manic-like b...

Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu… in Journal of Neuroinflammation (2024)

Article

Metabolic subtypes and immune landscapes in esophageal squamous cell carcinoma: prognostic implications and potential for personalized therapies

This study aimed to identify metabolic subtypes in ESCA, explore their relationship with immune landscapes, and establish a metabolic index for accurate prognosis assessment.

**ao-wan Yu, Pei-wei She, Fang-chuan Chen, Ya-yu Chen, Shuang Zhou… in BMC Cancer (2024)

Article

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling

Chemoresistance is a major clinical challenge that leads to tumor metastasis and poor clinical outcome. The mechanisms underlying gastric cancer resistance to chemotherapy are still unclear.

Long-Long Cao, Yu-Kai Wu, Tong-**n Lin, Mi Lin, Yu-**g Chen… in Cancer Cell International (2023)

Article

Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG

The role of PRKAG2 in the maintenance of heart function is well established, but little is known about how PRKAG2 is regulated in cardiomyocytes. In this study, we investigated the role of the lncRNA PRKAG2-AS, w...

**ao-Wei Song, Ting Su, Bo Li, Yun-Jie Huang, Wen-**a He… in Clinical Epigenetics (2023)

Article

Efficacy of concurrent chemoradiotherapy alone for loco-regionally advanced nasopharyngeal carcinoma: long-term follow-up analysis

To analysis the clinical outcomes of concurrent chemoradiotherapy (CCRT) alone based on 10-year results for loco-regionally advanced nasopharyngeal carcinoma (LANPC), so as to provide evidence for individualiz...

An-An Xu, **g-**g Miao, Lin Wang, An-Chuan Li, Fei Han… in Radiation Oncology (2023)

Article

Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer

Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (ln...

Che-Yuan Hu, Bing-Hua Su, Ya-Che Lee, Chung-Teng Wang… in Journal of Biomedical Science (2022)

Article

Correction to: Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines

Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang… in NeuroMolecular Medicine (2022)

Article

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

The multi-generation heredity trait of hypertension in human has been reported, but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure. Recent evidence shows that...

**ao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-**g Lai… in Acta Pharmacologica Sinica (2022)

Article

Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3

Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- or a...

Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao… in Journal of Neuroinflammation (2022)

Article

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses, human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing to host defense. Cont...

Weiqi Hong, **gyun Yang, Jun Zou, Zhenfei Bi, Cai He… in Cellular & Molecular Immunology (2022)

Article

Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice

Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells ...

Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang… in Journal of Biomedical Science (2022)

Article

Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition

Immune checkpoint blockade has shown significant clinical benefit in multiple cancer indications, but many patients are either refractory or become resistant to the treatment over time. HER2/neu oncogene overe...

Chang-ling Gu, Hai-xia Zhu, Lan Deng, **ao-qing Meng, Kai Li… in Acta Pharmacologica Sinica (2022)

Article

d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays...

Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu… in Molecular Medicine (2021)

Article

The efficacy of anti-EGFR therapy in treating metastatic colorectal cancer differs between the middle/low rectum and the left-sided colon

Clinically, metastatic rectal cancer has been considered a subset of left-sided colon cancer. However, heterogeneity has been proposed to exist between high and middle/low rectal cancers. We aimed to examine t...

Kun-Han Lee, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang… in British Journal of Cancer (2021)

Article

Development of Improved Mumps Vaccine Candidates by Mutating Viral mRNA Cap Methyltransferase Sites in the Large Polymerase Protein

Although a live attenuated vaccine is available for controlling mumps virus (MuV), mumps still outbreaks frequently worldwide. The attenuated MuV vaccine strain S79 is widely used in mumps vaccination in China...

**aoqiang Hao, Yilong Wang, Mengying Zhu, Dongming Zhou, Rongxian Liu… in Virologica Sinica (2021)

Article

Genetic characteristics and epidemiology of inherited retinal degeneration in Taiwan

Inherited retinal degenerations (IRDs) are a group of phenotypically and genotypically heterogeneous disorders with substantial socioeconomic impact. In this cohort study, we tried to address the genetic chara...

Ta-Ching Chen, Ding-Siang Huang, Chao-Wen Lin, Chang-Hao Yang… in npj Genomic Medicine (2021)