64 Result(s)

Article

Harnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**

The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity and non-target-ce...

Hui-Da Li, Yuan-Qiang Chen, Yan Li, **ng Wei, Si-Yi Wang, Ying Cao… in Nature Communications (2024)

Article

Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion

The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identif...

Ya Fang, Jia-** Wan, Zheng Wang, Shi-Yang Song, Cao-Xu Zhang… in Nature Communications (2024)

Article

Low pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides

Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric ef...

Yi-Hong Gao, Dong-Hui Wang, Feng-**a Hu, Qing-Zhen Huang… in Nature Communications (2024)

Article

Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive und...

Lijun Ning, Yi-Lu Zhou, Han Sun, Youwei Zhang, Chaoqin Shen… in Nature Communications (2023)

Article

Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough...

Chang-Run Guo, Zhong-Zhe Zhang, **ng Zhou, Meng-Yang Sun… in Nature Communications (2023)

Article

Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids

Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. However, the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in early human embryos rem...

Hao Wu, **ng-Yao Huang, Meng-Xu Sun, Yue Wang, Hang-Yu Zhou… in Nature Communications (2023)

Article

Urinary miR-16-5p can be used as a potential marker of endocapillary hypercellularity in IgA nephropathy

The most prevalent primary glomerulonephritis and leading cause of end-stage renal disease worldwide is IgA nephropathy (IgAN). More and more studies are describing urinary microRNA (miRNA) as a non-invasive m...

Meng Zhang, Zhi-Yu Duan, Qiu-Yue Zhang, **e-Guan-Xuan Xu, Yan Zhang… in Scientific Reports (2023)

Article

Publisher Correction: Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis

Feng Li, Tong‑Yue Du, Li‑Da Wu, Lei Zhang, Huan‑Huan Liu… in Scientific Reports (2023)

Article

Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis

Dilated cardiomyopathy (DCM) is characterized by the left ventricular dilatation and impaired myocardial systolic dysfunction with high mortality and morbidity. However, the underlying mechanisms remain elusiv...

Feng Li, Tong-Yue Du, Li-Da Wu, Lei Zhang, Huan-Huan Liu… in Scientific Reports (2023)

Article

CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I

Chromosome segregation is initiated by cohesin degradation, which is driven by anaphase-promoting complex/cyclosome (APC/C). Chromosome cohesin is removed by activated separase, with the degradation of securin...

Cheng-Jie Zhou, **ng-Yue Wang, Yan-Hua Dong, Dong-Hui Wang… in Nature Communications (2022)

Article

A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma

Novel neoadjuvant therapy regimens are warranted for oral squamous cell carcinoma (OSCC). In this phase I trial (NCT04393506), 20 patients with locally advanced resectable OSCC receive three cycles of camreliz...

Wu-tong Ju, Rong-hui **a, Dong-wang Zhu, Sheng-** Dou… in Nature Communications (2022)

Article

Coronaviruses exploit a host cysteine-aspartic protease for replication

Highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus 2 (refs. ^1,2) (SARS-CoV-2), Middle East respiratory syndrome coronavirus³ (MERS-CoV) and SARS-CoV-1 (ref. ⁴), vary in their...

Hin Chu, Yuxin Hou, Dong Yang, Lei Wen, Hui** Shuai, Chaemin Yoon, Jialu Shi… in Nature (2022)

Article

Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...

Chun-Hong Jia, Zhou-Shan Feng, **ao-Jun Lin, Qi-Liang Cui… in Scientific Reports (2022)

Article

Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto’s thyroiditis

Hashimoto’s thyroiditis (HT) is the most common autoimmune disease characterized by lymphocytic infiltration and thyrocyte destruction. Dissection of the interaction between the thyroidal stromal microenvironm...

Qian-Yue Zhang, **ao-** Ye, Zheng Zhou, Chen-Fang Zhu, Rui Li… in Nature Communications (2022)

Article

High prevalence of bla_CTX-M and bla_SHV among ESBL producing E. coli isolates from beef cattle in China’s Sichuan-Chongqing Circle

Enterobacteria that produce extended-spectrum β-lactamase (ESBL) such as Escherichia coli (E. coli) are common in our environment and known to cause serious health implications in humans and animals. β-lactam ant...

Yu-Long Zhang, Fang-Yuan Huang, Lin-Li Gan, **n Yu, Dong-Jie Cai… in Scientific Reports (2021)

Article

Genome-wide association studies provide insights into the genetic determination of fruit traits of pear

Pear is a major fruit tree crop distributed worldwide, yet its breeding is a very time-consuming process. To facilitate molecular breeding and gene identification, here we have performed genome-wide associatio...

Ming-Yue Zhang, Cheng Xue, Hongju Hu, Jiaming Li, Yongsong Xue… in Nature Communications (2021)

Article

Perioperative anti-vascular endothelial growth factor agents treatment in patients undergoing vitrectomy for complicated proliferative diabetic retinopathy: a network meta-analysis

Currently, controversies regarding the optimal time-point of anti-vascular endothelial growth factor (VEGF) pretreatment before pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) still ex...

Dong-yue Wang, **n-yu Zhao, Wen-fei Zhang, Li-hui Meng, You-xin Chen in Scientific Reports (2020)

Article

Machine learning based early warning system enables accurate mortality risk prediction for COVID-19

Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. ...

Yue Gao, Guang-Yao Cai, Wei Fang, Hua-Yi Li, Si-Yuan Wang… in Nature Communications (2020)