27 Result(s)

Article

Micafungin exerts antitumor effect on breast cancer and osteosarcoma through preventing EMT in tumor cells in an USP7/AKT/GSK-3β pathway-dependent manner

Breast cancer and osteosarcoma are common cancers in women and children, respectively, but ideal drugs for treating patients with breast cancer or osteosarcoma remain to be found. Micafungin is an antifungal d...

Qian-Lin Wang, Li Wang, Qiong-Yu Li… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

Article

Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice

The pathophysiology of autism spectrum disorders (ASDs) is causally linked to postsynaptic scaffolding proteins, as evidenced by numerous large-scale genomic studies [1, 2] and in vitro and in vivo neurobiologica...

Tian-Jie Lyu, Ji Ma, **-Yin Zhang, Guo-Guang **e, Cheng Liu… in Molecular Psychiatry (2024)

Article

Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human

Inappropriate aggression in humans hurts the society, families and individuals. The genetic basis for aggressive behavior, however, remains largely elusive. In this study, we identified two rare missense varia...

Shi-**ao Peng, **gwen Pei, Berardo Rinaldi, Jiang Chen, Yu-Han Ge… in Molecular Psychiatry (2022)

Article

KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor

Qing-Qing Li, Jiang Chen, ** Hu, Min Jia, Jia-Hui Sun… in Molecular Psychiatry (2022)

Article

Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory

N-methyl-D-aspartic acid type glutamate receptors (NMDARs) play critical roles in synaptic transmission and plasticity, the dysregulation of which leads to cognitive defects. Here, we identified a rare variant...

Qing-Qing Li, Jiang Chen, ** Hu, Min Jia, Jia-Hui Sun… in Molecular Psychiatry (2022)

Article

Effects of Chemotherapy on Neuroinflammation, Neuronal Damage, Neurogenesis, and Behavioral Performance in Bone Marrow Transplantation Recipient Mice

As bone marrow transplant (BMT) is gradually applied to the study of central nervous system (CNS) disease, it is needed to investigate the proper dose of chemotherapy to eradicate bone marrow cells while bring...

Zhong-Yuan Yu, Man-Yu Xu, Zhi-Hao Liu, Gui-Hua Zeng, Huan Fan… in Neurotoxicity Research (2022)

Article

Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory

Exposure to drugs of abuse induces alterations of dendritic spine morphology and density that has been proposed to be a cellular basis of long-lasting addictive memory and heavily depend on remodeling of its u...

Yu-Jun Wang, Chuan Yu, Wei-Wei Wu, Yun-Yue Ju, Yao Liu, Chi Xu… in Molecular Psychiatry (2021)

Article

Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

Gemcitabine-cisplatin (GP) chemotherapy is the standard first-line systemic treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). In this international, double-blind, phase 3 trial (Clinical...

Hai-Qiang Mai, Qiu-Yan Chen, Dong** Chen, Chaosu Hu, Kunyu Yang… in Nature Medicine (2021)

Article

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancest...

Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler… in Molecular Psychiatry (2021)

Article

Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease (sAD) and pathological biomarkers in cerebrospinal fluid (CSF), 462 sAD patients and 463 age-matched cognitive...

Wei-Wei Li, Zhen Wang, Dong-Yu Fan, Ying-Ying Shen, Dong-Wan Chen… in Neuroscience Bulletin (2020)

Article

Evolution of the vestibular function during head impulses in spinocerebellar ataxia type 6

Evolution of vestibular function requires further elucidation in spinocerebellar ataxia (SCA). This study aimed to determine temporal evolution in the findings of head impulse tests (HITs) in SCA type 6 (SCA6)...

Sun-Uk Lee, Ji-Soo Kim, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Yun Park… in Journal of Neurology (2020)

Article

Lentiviral gene therapy for X-linked chronic granulomatous disease

Chronic granulomatous disease (CGD) is a rare inherited disorder of phagocytic cells^1,2. We report the initial results of nine severely affected X-linked CGD (X-CGD) patients who received ex vivo autologous CD34⁺

Donald B. Kohn, Claire Booth, Elizabeth M. Kang, Sung-Yun Pai… in Nature Medicine (2020)

Article

Genetic Association Between NGFR, ADAM17 Gene Polymorphism, and Parkinson’s Disease in the Chinese Han Population

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by neuronal loss in the substantia nigra. The p75 neurotrophin receptor (p75NTR, encoded by NGFR) was found to play an important role i...

Wei-Wei Li, Ying-Ying Shen, Dong-Wan Chen, Hui-Yun Li… in Neurotoxicity Research (2019)

Article

Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury

Cerebral ischemic injury is a leading cause of human mortality and disability, seriously threatening human health in the world. Activin A (Act A), as a well-known neuroprotective factor, could alleviate ischem...

Jiao-Qi Wang, Yue Dong, Si-Jia Li, Cheng-Liang Pan, Hong-Yu Liu… in Neurochemical Research (2019)