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  1. No Access

    Article

    Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice

    The pathophysiology of autism spectrum disorders (ASDs) is causally linked to postsynaptic scaffolding proteins, as evidenced by numerous large-scale genomic studies [1, 2] and in vitro and in vivo neurobiologica...

    Tian-Jie Lyu, Ji Ma, **-Yin Zhang, Guo-Guang **e, Cheng Liu… in Molecular Psychiatry (2024)

  2. No Access

    Article

    Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human

    Inappropriate aggression in humans hurts the society, families and individuals. The genetic basis for aggressive behavior, however, remains largely elusive. In this study, we identified two rare missense varia...

    Shi-**ao Peng, **gwen Pei, Berardo Rinaldi, Jiang Chen, Yu-Han Ge… in Molecular Psychiatry (2022)

  3. No Access

    Article

    KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor

    Qing-Qing Li, Jiang Chen, ** Hu, Min Jia, Jia-Hui Sun… in Molecular Psychiatry (2022)

  4. No Access

    Article

    Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory

    N-methyl-D-aspartic acid type glutamate receptors (NMDARs) play critical roles in synaptic transmission and plasticity, the dysregulation of which leads to cognitive defects. Here, we identified a rare variant...

    Qing-Qing Li, Jiang Chen, ** Hu, Min Jia, Jia-Hui Sun… in Molecular Psychiatry (2022)

  5. Article

    Open Access

    Associations of plasma angiostatin and amyloid-β and tau levels in Alzheimer’s disease

    Angiostatin, an endogenous angiogenesis inhibitor generated by the proteolytic cleavage of plasminogen, was recently reported to contribute to the development of Alzheimer’s disease (AD). However, whether ther...

    Yuan Cheng, Jun-Rong Ren, Jie-Ming Jian, Chen-Yang He… in Translational Psychiatry (2022)

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  6. No Access

    Article

    Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory

    Exposure to drugs of abuse induces alterations of dendritic spine morphology and density that has been proposed to be a cellular basis of long-lasting addictive memory and heavily depend on remodeling of its u...

    Yu-Jun Wang, Chuan Yu, Wei-Wei Wu, Yun-Yue Ju, Yao Liu, Chi Xu… in Molecular Psychiatry (2021)

  7. No Access

    Article

    Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

    Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancest...

    Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler… in Molecular Psychiatry (2021)