36 Result(s)

Article

Physical frailty, genetic predisposition, and incident dementia: a large prospective cohort study

Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical f...

Pei-Yang Gao, Ling-Zhi Ma, Xue-Jie Wang, Bang-Sheng Wu… in Translational Psychiatry (2024)

Article

D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels

The potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 2 (TPH2) is well characterized to facilitate rapid and long-lasting antid...

Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan… in Translational Psychiatry (2023)

Article

Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway

Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expressed in the liver, and patients with mutations in B4GALT1 exhibit hepatopathy. However, t...

Po-Da Chen, Ying-Yu Liao, Yu-Chia Cheng, Hsin-Yi Wu, Yao-Ming Wu… in Oncogenesis (2023)

Article

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously reported that single nucleotide polymorphisms spanni...

Zhi-Hui Yang, **n Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, **-Hua Huo… in BMC Medicine (2023)

Article

Mitochondrial diseases in Hong Kong: prevalence, clinical characteristics and genetic landscape

To determine the prevalence of mitochondrial diseases (MD) in Hong Kong (HK) and to evaluate the clinical characteristics and genetic landscape of MD patients in the region.

Tsz-sum Wong, Kiran M. Belaramani, Chun-kong Chan… in Orphanet Journal of Rare Diseases (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells

Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function in esophageal squamous carcinoma (ESCC) are poorly unde...

Wenting He, Shiyong Lin, Yi Guo, Yuanzhong Wu, Lu-Lu Zhang, Qiling Deng… in Oncogene (2022)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)

Article

Correction to: Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

Chen-Fei Zhou, **g Ma, Lei Huang, Hong-Yan Yi, Yan-Mei Zhang, **ang-Guang Wu… in Oncogene (2022)

Article

Hematopoietic stem cell transplantation activity in China 2019: a report from the Chinese Blood and Marrow Transplantation Registry Group

Between 2008 and 2019, 58,914 hematopoietic stem cell transplantations (HSCTs) were reported to the Chinese Blood and Marrow Transplantation Registry Group (CBMTRG) throughout China. In this report, we focus o...

Lan-** Xu, Pei-Hua Lu, De-Pei Wu, Zi-Min Sun, Qi-Fa Liu… in Bone Marrow Transplantation (2021)

Article

Disrupted intrinsic functional brain topology in patients with major depressive disorder

Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...

Hong Yang, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Molecular Psychiatry (2021)

Article

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, do...

Jiang-Ming Chen, Wei-Jian Zhu, Jie Liu… in Signal Transduction and Targeted Therapy (2021)

Article

NR4A3 and CCL20 clusters dominate the genetic networks in CD146⁺ blood cells during acute myocardial infarction in humans

CD146 is a tight junction-associated molecule involved in maintaining endothelial barrier, and balancing immune–inflammation response, in cardiovascular disease. Notably, peripheral CD146⁺ cells significantly ups...

Yan-hui Wang, Chen-xin Li, Jessica M. Stephenson… in European Journal of Medical Research (2021)

Article

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with high heterogeneity. Precise subtypes with distinct genomic and/or gene expression patterns have been recentl...

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang… in Frontiers of Medicine (2021)

Article

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs, targeted therapeutic drugs have become mainstream cancer treatments. Since the first tyrosine kinase inhibitor imatini...

Lei Zhong, Yueshan Li, Liang **ong… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

An-Guo Wu, Rong Pan, Betty Yuen-Kwan Law… in Signal Transduction and Targeted Therapy (2021)

Article

Circulating level of microRNA-142-5p is a potential biomarker for predicting in-stent restenosis: a case–control study

Patients who receive percutaneous coronary intervention (PCI) have different chances of develo** in-stent restenosis (ISR). To date, no predictable biomarker can be applied in the clinic. MicroRNAs (miRNAs o...

Chun-Hsu Pan, Shu-Chen Chien, Chang-Jui Chen… in BMC Cardiovascular Disorders (2021)

Article

Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostl...

Si-Ye Chen, Yong Yang, Shu-Nan Qi, Ying Wang, Chen Hu, **a He, Li-Ling Zhang… in Leukemia (2021)

Article

Natural course of coronary artery calcium progression in Asian population with an initial score of zero

We aimed to investigate the natural course of coronary artery calcium progression in an Asian population with a baseline coronary artery calcium (CAC) score of zero, and to determine subclinical coronary ather...

Yi-Wen Shen, Yun-Ju Wu, Yi-Chi Hung, Chia-Chi Hsiao… in BMC Cardiovascular Disorders (2020)

Article

Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China

Since December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric ...

Fang Zheng, Chun Liao, Qi-hong Fan, Hong-bo Chen, Xue-gong Zhao… in Current Medical Science (2020)