52 Result(s)

Article

Preoperative evaluation of mediastinal lymph nodes in non-small cell lung cancer using [⁶⁸Ga]FAPI-46 PET/CT: a prospective pilot study

Mediastinal nodal staging is crucial for surgical candidate selection in non-small cell lung cancer (NSCLC), but conventional imaging has limitations often necessitating invasive staging. We investigated the a...

Yeon-koo Kang, Kwon Joong Na, Jimyung Park… in European Journal of Nuclear Medicine and M… (2024)

Article

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a ‘highly transmissible respiratory pathogen, leading to severe multi-organ damage. However, knowledge regarding SARS-CoV-2-induced cellular alte...

Hye ** Shin, Wooseong Lee, Keun Bon Ku… in Signal Transduction and Targeted Therapy (2024)

Article

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP

Mutations resulting in decreased activity of p53 tumor suppressor protein promote tumorigenesis. P53 protein levels are tightly regulated through the Ubiquitin Proteasome System (UPS). Several E3 ligases were ...

Ruqaia Abbas, Oliver Hartmann, Dorin Theodora Asiss, Rabab Abbas, Julia Kagan… in Apoptosis (2024)

Article

Correction: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial

Jung Hyun Jo, Yong-Tae Kim, Ho Soon Choi, Ho Gak Kim… in British Journal of Cancer (2024)

Article

Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial

The TeloVac study indicated GV1001 did not improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC). However, the cytokine examinations suggested that high serum eotaxin levels may predict resp...

Jung Hyun Jo, Yong-Tae Kim, Ho Soon Choi, Ho Gak Kim… in British Journal of Cancer (2024)

Article

Genomic and evolutionary characteristics of metastatic gastric cancer by routes

In gastric cancer (GC) patients, metastatic progression through the lymphatic, hematogenous, peritoneal, and ovarian routes, is the ultimate cause of death. However, the genomic and evolutionary characteristic...

Jae Eun Lee, Ki Tae Kim, Su-** Shin, Jae-Ho Cheong… in British Journal of Cancer (2023)

Article

^99mTc-MAA accumulation within tumor in preoperative lung perfusion SPECT/CT associated with occult lymph node metastasis in patients with clinically N0 non-small cell lung cancer

^99mTc-MAA accumulation within the tumor representing pulmonary arterial perfusion, which is variable and may have a clinical significance. We evaluated the prognostic significance of ^99mTc-MAA distribution within...

Vanessa Murad, Minseok Suh, Hongyoon Choi, Gi Jeong Cheon, Kwon Joong Na… in BMC Cancer (2023)

Article

High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated.

Sehui Kim, Jaemoon Koh, Seung Geun Song, Jeemin Yim, Miso Kim, Bhumsuk Keam… in BMC Cancer (2022)

Article

Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation

Acute myeloid leukemia (AML) is an aggressive blood cancer with poor clinical outcomes. Emerging data suggest that mitochondrial oxidative phosphorylation (mtOXPHOS) plays a significant role in AML tumorigenes...

Wonhyoung Seo, Seungyeul Yoo, Yi Zhong, Sang-Hee Lee… in Journal of Hematology & Oncology (2022)

Article

The prevalence of homologous recombination deficiency (HRD) in various solid tumors and the role of HRD as a single biomarker to immune checkpoint inhibitors

Homologous recombination deficiency (HRD) is related to tumorigenesis. Currently, the possibility of HRD as a prognostic biomarker to immune checkpoint inhibitors is unknown. We aimed to investigate whether HR...

Hana Kim, Soomin Ahn, Hongsik Kim… in Journal of Cancer Research and Clinical On… (2022)

Article

Improving anticancer effect of aPD-L1 through lowering neutrophil infiltration by PLAG in tumor implanted with MB49 mouse urothelial carcinoma

The PD-L1 antibody is an immune checkpoint inhibitor (ICI) attracting attention. The third-generation anticancer drug has been proven to be very effective due to fewer side effects and higher tumor-specific re...

Guen Tae Kim, Eun Young Kim, Su-Hyun Shin, Hyowon Lee, Se Hee Lee… in BMC Cancer (2022)

Article

Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma

Mucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and genomic characteristics of MGC have not been well evaluated.

Jae Eun Lee, Yoon Young Choi, Ji Yeong An, Ki Tae Kim, Su-** Shin… in Gastric Cancer (2022)

Article

Interventricular septal hematoma detected by transesophageal echocardiography after congenital heart surgery in an infant: a case report

Interventricular septal hematoma is an extremely rare complication following congenital heart surgery. During cardiac surgery, interventricular septal hematomas can be detected only by intraoperative transesop...

Young-Eun Jang, **-Tae Kim, Ji-Hyun Lee in European Journal of Medical Research (2021)

Article

Comparison between FOLFIRINOX and gemcitabine plus nab-paclitaxel including sequential treatment for metastatic pancreatic cancer: a propensity score matching approach

FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GnP) have been recommended as the first-line chemotherapy for metastatic pancreatic cancer (mPC). However, the evidence is lacking comparing not only two r...

Jung Won Chun, Sang Hyub Lee, Joo Seong Kim, Namyoung Park, Gunn Huh… in BMC Cancer (2021)

Article

Prognostic significance of sarcopenia in microsatellite-stable gastric cancer patients treated with programmed death-1 inhibitors

Sarcopenia has been underscored as a significant predictor of poor prognosis in cancer patients undergoing immunotherapy with programmed death-1 (PD-1) inhibitors. We aimed to investigate the prognostic signif...

Yeun-Yoon Kim, Jeeyun Lee, Woo Kyoung Jeong, Seung Tae Kim, Jae-Hun Kim… in Gastric Cancer (2021)

Article

A randomised phase 2b study comparing the efficacy and safety of belotecan vs. topotecan as monotherapy for sensitive-relapsed small-cell lung cancer

This study compared the efficacy/safety of the camptothecin analogues belotecan and topotecan for sensitive-relapsed small-cell lung cancer (SCLC).

**-Hyoung Kang, Ki-Hyeong Lee, Dong-Wan Kim, Sang-We Kim… in British Journal of Cancer (2021)

Article

A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer

This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer.

Hee Seung Kim, Sang-Yoon Park, Chan-Yong Park, Young Tae Kim… in British Journal of Cancer (2021)

Article

High platelet-to-lymphocyte ratio is associated with poor prognosis in patients with unresectable intrahepatic cholangiocarcinoma receiving gemcitabine plus cisplatin

Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR)...

Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho… in BMC Cancer (2020)

Article

Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer

Poly (ADP-ribose) polymerase inhibitors targeting BRCA1/2 mutations are available for treating patients with high-grade serous ovarian cancer. These treatments may be more appropriately directed to patients who m...

Kyung ** Eoh, Hye Min Kim, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim… in BMC Cancer (2020)

Article

Germline BRCA, chemotherapy response scores, and survival in the neoadjuvant treatment of ovarian cancer

To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) follo...

Yong Jae Lee, Hyun-Soo Kim, John Hoon Rim, Jung-Yun Lee, Eun Ji Nam… in BMC Cancer (2020)